BOLL Antibody

1. hypermethylation of DAZL and BOULE promoters in human sperm is associated with human infertility PMID: 27358391
2. Our study demonstrated an oncogenic role of BOLL in CRC despite tumor-specific promoter hypermethylation. PMID: 25605553
3. demonstrate that Boll is also transiently expressed during oogenesis in the fetal mouse ovary, but is simultaneously co-expressed within the same germ cells as Dazl PMID: 24086306
4. Assessing the expression of both CDY1 and BOULE by qualitative RT-PCR is a sensitive and feasible test for predicting the presence of sperm cells in testicular tissue biopsies. PMID: 21474125
5. expression of spermatogenic phenotypes of partial AZFc deletions is independent of the variations in DAZL and BOULE in the Han population PMID: 19342699
6. BOULE may encode a key conserved switch that regulates progression of germ cells through meiosis in men. PMID: 12499397
7. Role in spermatogenesis. Decreased DAZ proteins in spermatogenic failure may be due to germ cell loss. Transcription of BOULE, DAZL, and DAZ not altered in degrees of spermatogenic failure. No increase of DAZL or BOULE found in DAZ deletion. PMID: 15066460
8. Major group of infertile men with meiotic arrest lack BOULE protein and its putative target, CDC25A expression. Spermatogenic failure may arise from factor(s) upstream of BOULE possibly involved in regulating transcription and/or translation of BOULE. PMID: 15070965
9. BOULE coding sequence mutations are not an important factor in the aetiology of azoospermia. PMID: 15379971
10. mutations in BOULE can be eliminated as a major cause of impaired spermatogenesis. PMID: 15705409
11. Among the three BOULE isoforms, B2 might have the major role for meiotic completion. PMID: 17114206
12. CDC25A is subject to translational control by BOLL, which is an evolutionarily conserved mechanism. PMID: 19417033
13. human DAZL (deleted in azoospermia-like) functions in primordial germ-cell formation, whereas closely related genes DAZ and BOULE (also called BOLL) promote later stages of meiosis and development of haploid gametes PMID: 19865085

Show More

Hide All

HGNC: 14273

OMIM: 606165

KEGG: hsa:66037

STRING: 9606.ENSP00000314792

UniGene: Hs.169797