CACNA2D3 Antibody

1. Nine of the 32 (28.1%) iCCA patients had gene mutations at chromosome 3p, totaling 11 mutations across five genes. Those included five (15.6%) BAP1 mutations, two each (6.3%) of CACNA2D3 and RASSF1 mutations, and one each (3.1%) of ATG7 and PLCD1 mutations. Six (18.8%) cases had concurrent loss of chromosome 3p and gene mutations. PMID: 29122566
2. Findings demonstrate the tumor suppressive role of CACNA2D3 in gliomas. CACNA2D3 operates via Ca 2thorn signaling and the activation of non-canonical Wnt signaling to inhibit cell proliferation and motility and induce apoptosis. PMID: 27583705
3. The risk of developing anaemia is increased in reproductive age women carriers of A allele of rs1868505 (CACNA2D3) and/or T allele of rs13194491 (HIST1H2BJ). PMID: 26460247
4. CACNA2D3-mediated increase in intracellular calcium (Ca2+) can induce mitochondrial-mediated apoptosis. PMID: 23649311
5. CACNA2D3 is a novel tumor suppressor gene responsible for the 3p21 deletion event that plays a critical suppressing role in the development and progression of esophageal squamous cell carcinoma. PMID: 23560067
6. CACNA2D3 polymorphism rs1375515 plays important role in iron status and is associated with the levels of iron-related biomarkers, as well as with iron clinical phenotypes (normal, iron de fi cient and anaemic). PMID: 23324578
7. Expression of CACNA2D3 mRNA is regulated in breast cancer cell lines by methylation in the CpG island located in the 5' regulatory region of the gene. PMID: 22644305
8. High CACNA2D3 gene expression is assiciated with glioblastoma multiforme. PMID: 22395973
9. In humans, study found single-nucleotide polymorphisms in alpha2delta3 that are associated with reduced acute heat pain sensitivity in healthy volunteers and chronic postsurgical back pain. PMID: 21074052
10. did not detect submicroscopic deletion or duplication nor sequence alteration in either CACNA2D3 or WNT5A in ZLS-affected individuals PMID: 17937436
11. Loss of CACNA2D3 expression through aberrant promoter hypermethylation may contribute to gastric carcinogenesis. PMID: 18588891
12. This publication primarily discusses the alpha2/delta 4 subunit, but also contains cDNA data relating to the gene described in this record. PMID: 12181424

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HGNC: 15460

OMIM: 606399

KEGG: hsa:55799

STRING: 9606.ENSP00000419101

UniGene: Hs.656687