CAPZA1 Antibody

Datasheet

Code	CSB-PA004510LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: THP-1 whole cell lysate All lanes: CAPZA1 antibody at 3µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 33 kDa Observed band size: 33 kDa Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA004510LA01HU at dilution of 1:100 Immunofluorescent analysis of HepG2 cells using CSB-PA004510LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
Citations
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CAPZA1 Polyclonal antibody

Uniprot No.

P52907

Target Names

CAPZA1

Alternative Names

Cap Z antibody; Cappa 1 antibody; Cappa1 antibody; Capping protein (actin filament) muscle Z line alpha 1 antibody; Capping protein alpha 1 antibody; Capping protein muscle Z line alpha 1 antibody; CapZ alpha 1 antibody; CapZ alpha-1 antibody; CAPZ antibody; CAPZA 1 antibody; Capza1 antibody; CAZ 1 antibody; CAZ1 antibody; CAZA1_HUMAN antibody; F actin capping protein alpha 1 subunit antibody; F-actin-capping protein subunit alpha-1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human F-actin-capping protein subunit alpha-1 protein (211-252AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CAPZA1 Antibody (Product code: CSB-PA004510LA01HU) is Non-conjugated. For CAPZA1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA004510LB01HU	CAPZA1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA004510LC01HU	CAPZA1 Antibody, FITC conjugated
Biotin	CSB-PA004510LD01HU	CAPZA1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Citations

Research Article Long-Read Nanopore Sequencing Identifies Mismatch Repair-Deficient Related Genes with Alternative Splicing in Colorectal Cancer H Qu,Disease markers,2022
Long-Read Nanopore Sequencing Identifies Mismatch Repair-Deficient Related Genes with Alternative Splicing in Colorectal Cancer H Qu,Disease Markers,2022

Customer Reviews and Q&A

■ Customer Reviews

Average Rating:

5.0 - 2 reviews

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Applications : Immunohistochemistry (IHC)

Review: Immunohistochemistry (IHC) assays determine the overexpression of screened genes. (a) Representative IHC pictures show the expression of INHBA, RPL22L1, and CAPZA1 in tissue splices obtained from the same sample.

By Anonymous

Applications : Immunohistochemistry (IHC)

Sample type: cell

Review: Immunohistochemistry (IHC) assays determine the overexpression of screened genes. Representative IHC pictures show the expression of INHBA, RPL22L1, and CAPZA1 in tissue splices obtained from the same sample.

By Anonymous

Target Background

Function

F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions.

Gene References into Functions

Data show that CAPZA1 inhibits EMT in hepatocellular carcinoma (HCC cells by regulating actin cytoskeleton remodeling, thereby reducing the metastatic ability of the cells. PMID: 28093067
Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ alpha-1) and profilin 2. PMID: 26764407
mDia1 displaced from the barbed end by CapZ Actin Capping Protein can randomly slide along the actin filament and later return. PMID: 26566078
The present study suggests that CAPZA1 could be a marker of good prognosis in gastric cancer and shows that CAPZA1 is associated with decreased cancer cell migration and invasion. PMID: 23545944
CAPAZA1 is over expressed in malignant melanoma. PMID: 21566537
V-1, a protein expressed transiently during murine cerebellar development, regulates actin polymerization via interaction with capping protein PMID: 12488317
Cd2 antigen is linked to this protein via CMS and CIN85. PMID: 12690097
CKIP-1 has a role in cell morphology that depends on its interaction with actin-capping protein PMID: 16987810
Damaging exercise induced the expression of capZalpha, MCIP1, CARP1, DNAJB2, c-myc, and junD, each of which are likely involved in skeletal muscle growth, remodeling, and stress management. PMID: 18321953

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Subcellular Location

Cytoplasm, cytoskeleton.

Protein Families

F-actin-capping protein alpha subunit family

Database Links

HGNC: 1488

OMIM: 601580

KEGG: hsa:829

STRING: 9606.ENSP00000263168

UniGene: Hs.744974

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Endocytosis

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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