CAPZA1 Antibody

Code CSB-PA004510LA01HU
Size US$299 How to order?
Image
  • Western Blot
    Positive WB detected in: THP-1 whole cell lysate
    All lanes: CAPZA1 antibody at 3µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 33 kDa
    Observed band size: 33 kDa

  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA004510LA01HU at dilution of 1:100

  • Immunofluorescent analysis of HepG2 cells using CSB-PA004510LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) CAPZA1 Polyclonal antibody
Uniprot No. P52907
Target Names CAPZA1
Alternative Names Cap Z antibody; Cappa 1 antibody; Cappa1 antibody; Capping protein (actin filament) muscle Z line alpha 1 antibody; Capping protein alpha 1 antibody; Capping protein muscle Z line alpha 1 antibody; CapZ alpha 1 antibody; CapZ alpha-1 antibody; CAPZ antibody; CAPZA 1 antibody; Capza1 antibody; CAZ 1 antibody; CAZ1 antibody; CAZA1_HUMAN antibody; F actin capping protein alpha 1 subunit antibody; F-actin-capping protein subunit alpha-1 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human F-actin-capping protein subunit alpha-1 protein (211-252AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated

The CAPZA1 Antibody (Product code: CSB-PA004510LA01HU) is Non-conjugated. For CAPZA1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA004510LB01HU CAPZA1 Antibody, HRP conjugated ELISA
FITC CSB-PA004510LC01HU CAPZA1 Antibody, FITC conjugated
Biotin CSB-PA004510LD01HU CAPZA1 Antibody, Biotin conjugated ELISA
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA, WB, IHC, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:20-1:200
IF 1:50-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Applications : Immunohistochemistry (IHC)

Review: Immunohistochemistry (IHC) assays determine the overexpression of screened genes. (a) Representative IHC pictures show the expression of INHBA, RPL22L1, and CAPZA1 in tissue splices obtained from the same sample.

By Anonymous

Target Background

Function
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions.
Gene References into Functions
  1. Data show that CAPZA1 inhibits EMT in hepatocellular carcinoma (HCC cells by regulating actin cytoskeleton remodeling, thereby reducing the metastatic ability of the cells. PMID: 28093067
  2. Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ alpha-1) and profilin 2. PMID: 26764407
  3. mDia1 displaced from the barbed end by CapZ Actin Capping Protein can randomly slide along the actin filament and later return. PMID: 26566078
  4. The present study suggests that CAPZA1 could be a marker of good prognosis in gastric cancer and shows that CAPZA1 is associated with decreased cancer cell migration and invasion. PMID: 23545944
  5. CAPAZA1 is over expressed in malignant melanoma. PMID: 21566537
  6. V-1, a protein expressed transiently during murine cerebellar development, regulates actin polymerization via interaction with capping protein PMID: 12488317
  7. Cd2 antigen is linked to this protein via CMS and CIN85. PMID: 12690097
  8. CKIP-1 has a role in cell morphology that depends on its interaction with actin-capping protein PMID: 16987810
  9. Damaging exercise induced the expression of capZalpha, MCIP1, CARP1, DNAJB2, c-myc, and junD, each of which are likely involved in skeletal muscle growth, remodeling, and stress management. PMID: 18321953

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Subcellular Location Cytoplasm, cytoskeleton.
Protein Families F-actin-capping protein alpha subunit family
Database Links

HGNC: 1488

OMIM: 601580

KEGG: hsa:829

STRING: 9606.ENSP00000263168

UniGene: Hs.744974

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