CAPZA1 Antibody

Code CSB-PA928245
Size US$166
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Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA928245(CAPZA1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA928245(CAPZA1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Product Details

Uniprot No.
Target Names
CAPZA1
Alternative Names
Cap Z antibody; Cappa 1 antibody; Cappa1 antibody; Capping protein (actin filament) muscle Z line alpha 1 antibody; Capping protein alpha 1 antibody; Capping protein muscle Z line alpha 1 antibody; CapZ alpha 1 antibody; CapZ alpha-1 antibody; CAPZ antibody; CAPZA 1 antibody; Capza1 antibody; CAZ 1 antibody; CAZ1 antibody; CAZA1_HUMAN antibody; F actin capping protein alpha 1 subunit antibody; F-actin-capping protein subunit alpha-1 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide of Human CAPZA1
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:1000-1:2000
IHC 1:25-1:100
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions.
Gene References into Functions
  1. Data show that CAPZA1 inhibits EMT in hepatocellular carcinoma (HCC cells by regulating actin cytoskeleton remodeling, thereby reducing the metastatic ability of the cells. PMID: 28093067
  2. Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ alpha-1) and profilin 2. PMID: 26764407
  3. mDia1 displaced from the barbed end by CapZ Actin Capping Protein can randomly slide along the actin filament and later return. PMID: 26566078
  4. The present study suggests that CAPZA1 could be a marker of good prognosis in gastric cancer and shows that CAPZA1 is associated with decreased cancer cell migration and invasion. PMID: 23545944
  5. CAPAZA1 is over expressed in malignant melanoma. PMID: 21566537
  6. V-1, a protein expressed transiently during murine cerebellar development, regulates actin polymerization via interaction with capping protein PMID: 12488317
  7. Cd2 antigen is linked to this protein via CMS and CIN85. PMID: 12690097
  8. CKIP-1 has a role in cell morphology that depends on its interaction with actin-capping protein PMID: 16987810
  9. Damaging exercise induced the expression of capZalpha, MCIP1, CARP1, DNAJB2, c-myc, and junD, each of which are likely involved in skeletal muscle growth, remodeling, and stress management. PMID: 18321953

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Subcellular Location
Cytoplasm, cytoskeleton.
Protein Families
F-actin-capping protein alpha subunit family
Database Links

HGNC: 1488

OMIM: 601580

KEGG: hsa:829

STRING: 9606.ENSP00000263168

UniGene: Hs.744974

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