CARD14 Antibody

Datasheet
Code CSB-PA060134
Size US$167
Uniprot No. Q9BXL6
Immunogen Synthesized peptide derived from the Internal region of Human CARD 14.
Raised in Rabbit
Species Reactivity Human,Mouse
Tested Applications IHC,IF,ELISA;IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/40000
Form Liquid
Conjugate Non-conjugated
Storage Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Alias CARD14; CARMA2; Caspase recruitment domain-containing protein 14; CARD-containing MAGUK protein 2; Carma 2
Immunogen Species Homo sapiens (Human)
Protocols Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
Target Names CARD14
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases
Involvement in disease Psoriasis 2 (PSORS2); Pityriasis rubra pilaris (PRP)
Subcellular Location Isoform 1: Cytoplasm, SUBCELLULAR LOCATION: Isoform 2: Cytoplasm, SUBCELLULAR LOCATION: Isoform 3: Cytoplasm
Tissue Specificity Isoform 1 is detected in placenta and epidermal keratinocytes (PubMed:22521418). Isoform 2 is detected in leukocytes and fetal brain (PubMed:22521418).
Database Links

HGNC: 16446

OMIM: 173200

KEGG: hsa:79092

STRING: 9606.ENSP00000344549

UniGene: Hs.675480

Pathway NF-kappa B signaling pathway

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