CARD14, caspase recruitment domain family member 14 or PRP, is a member of the MAGUK family. This protein, derived from human genes, plays a central role in immune and inflammatory responses by activating the NF-κB signaling pathway. CARD14 is particularly abundant in skin cells, where it is essential for maintaining the skin barrier and protecting against external pathogens. Abnormal activation of CARD14 is closely associated with the development of skin diseases such as psoriasis, potentially due to its role in promoting keratinocyte proliferation and inflammatory responses. Therefore, CARD14 is not only crucial for understanding skin biology and immune regulation but also represents a promising target for developing new therapies for skin disorders.
CARD14 Antibody (CSB-PA883622LA01HU)
Validated Data
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA883622LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA883622LA01HU at dilution of 1:100
Immunofluorescence staining of Hela cells with CSB-PA883622LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
The following CARD14 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
CARD14 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA004517GA01HU | CARD14 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA060134 | CARD14 Antibody | Human,Mouse | IHC, IF, ELISA |
CSB-PA592611 | CARD14 Antibody | Human | ELISA,WB,IHC |
CSB-PA448323 | CARD14 Antibody | Human,Mouse | ELISA,WB,IHC |
CSB-PA883622LA01HU | CARD14 Antibody | Human | ELISA, IHC, IF |
CARD14 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP860374MO CSB-EP860374MO CSB-BP860374MO CSB-MP860374MO CSB-EP860374MO-B |
Recombinant Mouse Caspase recruitment domain-containing protein 14 (Card14) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CARD14 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP883622HU CSB-EP883622HU CSB-BP883622HU CSB-MP883622HU CSB-EP883622HU-B |
Recombinant Human Caspase recruitment domain-containing protein 14 (CARD14), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |