CARD14 Antibody

Datasheet
Code CSB-PA592611
Former Code(s) CSB-PA128401
Size US$299
Uniprot No. Q9BXL6
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA592611(CARD14 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA592611(CARD14 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal brain tissue, Primary antibody: CSB-PA592611(CARD14 Antibody) at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes
Immunogen Fusion protein of Human CARD14
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA,WB,IHC;ELISA:1:1000-1:2000,WB:1:200-1:1000,IHC:1:25-1:100
Relevance This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants.
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias caspase recruitment domain family, member 14
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Target Names CARD14
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases
Involvement in disease Psoriasis 2 (PSORS2); Pityriasis rubra pilaris (PRP)
Subcellular Location Isoform 1: Cytoplasm, SUBCELLULAR LOCATION: Isoform 2: Cytoplasm, SUBCELLULAR LOCATION: Isoform 3: Cytoplasm
Tissue Specificity Isoform 1 is detected in placenta and epidermal keratinocytes (PubMed:22521418). Isoform 2 is detected in leukocytes and fetal brain (PubMed:22521418).
Database Links

HGNC: 16446

OMIM: 173200

KEGG: hsa:79092

STRING: 9606.ENSP00000344549

UniGene: Hs.675480

Pathway NF-kappa B signaling pathway

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