CARD18 Antibody

Datasheet

Code	CSB-PA004521LA01HU
Size	US$166
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Image	IHC image of CSB-PA004521LA01HU diluted at 1:100 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CARD18 Polyclonal antibody

Uniprot No.

P57730

Target Names

CARD18

Alternative Names

CARD18 antibody; ICEBERG antibody; UNQ5804/PRO19611Caspase recruitment domain-containing protein 18 antibody; Caspase-1 inhibitor Iceberg antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Caspase recruitment domain-containing protein 18 protein (1-90AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CARD18 Antibody (Product code: CSB-PA004521LA01HU) is Non-conjugated. For CARD18 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA004521LB01HU	CARD18 Antibody, HRP conjugated	ELISA
FITC	CSB-PA004521LC01HU	CARD18 Antibody, FITC conjugated
Biotin	CSB-PA004521LD01HU	CARD18 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B.

Gene References into Functions

In lesional epidermis of patients with lichen planus, CARD18 expression was either greatly diminished or entirely absent whereas in non-lesional areas expression was comparable to normal skin. PMID: 28506683
CARD18 expression differs in healthy and psoriatic skin; moreover, CARD18 demonstrated altered response under inflammatory conditions in healthy and psoriatic skin PMID: 27023378
CARD18 may be both a promising marker for prognosis and a target protein for treatment of gastric cancer. PMID: 23948415

Tissue Specificity

Primarily expressed in the heart and placenta.

Database Links

HGNC: 28861

OMIM: 605354

KEGG: hsa:59082

STRING: 9606.ENSP00000436691

UniGene: Hs.56279

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Service

Phage Display Service

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Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

NOD-like receptor signaling pathway

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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