CARD18 Antibody

Code CSB-PA004521LA01HU
Size US$166
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Image
  • IHC image of CSB-PA004521LA01HU diluted at 1:100 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CARD18 Polyclonal antibody
Uniprot No.
Target Names
CARD18
Alternative Names
CARD18 antibody; ICEBERG antibody; UNQ5804/PRO19611Caspase recruitment domain-containing protein 18 antibody; Caspase-1 inhibitor Iceberg antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Caspase recruitment domain-containing protein 18 protein (1-90AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The CARD18 Antibody (Product code: CSB-PA004521LA01HU) is Non-conjugated. For CARD18 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA004521LB01HU CARD18 Antibody, HRP conjugated ELISA
FITC CSB-PA004521LC01HU CARD18 Antibody, FITC conjugated
Biotin CSB-PA004521LD01HU CARD18 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B.
Gene References into Functions
  1. In lesional epidermis of patients with lichen planus, CARD18 expression was either greatly diminished or entirely absent whereas in non-lesional areas expression was comparable to normal skin. PMID: 28506683
  2. CARD18 expression differs in healthy and psoriatic skin; moreover, CARD18 demonstrated altered response under inflammatory conditions in healthy and psoriatic skin PMID: 27023378
  3. CARD18 may be both a promising marker for prognosis and a target protein for treatment of gastric cancer. PMID: 23948415
Tissue Specificity
Primarily expressed in the heart and placenta.
Database Links

HGNC: 28861

OMIM: 605354

KEGG: hsa:59082

STRING: 9606.ENSP00000436691

UniGene: Hs.56279

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