CARS Antibody

Datasheet

Code	CSB-PA004529LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: PC-3 whole cell lysate, Mouse lung tissue, Mouse kidney tissue All lanes: CARS antibody at 3µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 86, 83, 95 kDa Observed band size: 86 kDa Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA004529LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CARS Polyclonal antibody

Uniprot No.

P49589

Target Names

CARS

Alternative Names

Cysteine tRNA ligase antibody; Cars antibody; CysRS antibody; Cysteine--tRNA ligase antibody; Cysteinyl tRNA synthetase, cytoplasmic antibody; Cysteinyl-tRNA synthetase antibody; cytoplasmic antibody; MGC:11246 antibody; SYCC_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Cysteine--tRNA ligase, cytoplasmic protein (201-500AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CARS Antibody (Product code: CSB-PA004529LA01HU) is Non-conjugated. For CARS Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA004529LB01HU	CARS Antibody, HRP conjugated	ELISA
FITC	CSB-PA004529LC01HU	CARS Antibody, FITC conjugated
Biotin	CSB-PA004529LD01HU	CARS Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:2000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys).

Gene References into Functions

Four single nucleotide polymorphisms (SNPs) of CARS were significantly associated with gastric cancer risk in both the discovery stage and the validation stage PMID: 28409418
The risk (G and C) and non-risk (C and T) allele frequencies of the SNPs at the rs1888747 and rs739401 loci of FRMD3 and CARS, respectively, did not differ significantly between the diabetics with (case) and without (control) nephropathy (P > 0.05). PMID: 26909942
Loss of CARS, the cysteinyl-tRNA synthetase, suppresses ferroptosis induced by erastin, which inhibits the cystine-glutamate antiporter known as system xc(-). PMID: 26184909
CARS is a novel fusion partner of anaplastic lymphoma kinase in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor cases. PMID: 12112524
Specificity of anticodon recognition by human CysRS is higher than that of its bacterial counterparts. PMID: 17303165

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Involvement in disease

A chromosomal aberration involving CARS is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;11)(p23;p15) with ALK.

Subcellular Location

Cytoplasm.

Protein Families

Class-I aminoacyl-tRNA synthetase family

Database Links

HGNC: 1493

OMIM: 123859

KEGG: hsa:833

STRING: 9606.ENSP00000369897

UniGene: Hs.274873

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Service

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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