CASZ1 Antibody

1. Collectively, our proteomic, biochemical, genetic, and structural studies suggest that the physical interaction between TBX20 and CASZ1 is required for cardiac homeostasis, and further, that reduction or loss of this critical interaction leads to dilated cardiomyopathy (DCM) PMID: 28945738
2. These findings provide insight into mechanisms by which CASZ1 regulates transcription, and suggests that regulation of CASZ1 subcellular localization may impact its function in normal development and pathologic conditions such as NB tumorigenesis. PMID: 27270431
3. The current study reveals CASZ1 as a new gene responsible for human dilated cardiomyopathy (DCM), which provides novel mechanistic insight and potential therapeutic target for CASZ1-associated DCM, implying potential implications in improved prophylactic and therapeutic strategies for DCM, the most common type of primary myocardial disease. PMID: 28099117
4. the current study firstly identifies CASZ1 as a new gene predisposing to congenital heart disease in humans PMID: 27693370
5. CASZ1b binds to chromatin and recruits NuRD complexes to orchestrate epigenetic-mediated transcriptional programs PMID: 26296975
6. CASZ1 inhibits cell cycle progression in neuroblastoma by restoring retinoblastoma protein activity. PMID: 23892435
7. Papillomavirus DNA integration is associated with loss of CASZ1 gene and thus cervical carcinogenesis. PMID: 22262398
8. This study identifies key domains needed for CASZ1b to regulate gene transcription; a link between loss of CASZ1b transcriptional activity and attenuation of CASZ1b-mediated inhibition of neuroblastoma growth and tumorigenicity PMID: 22331471
9. determined that the tumor suppressors CLU, NGFR, and RUNX3 were also directly repressed by EZH2 like CASZ1 in NB cells PMID: 22068036
10. CASZ1 is a critical modulator of neural cell development, and that somatically acquired disruption of normal CASZ1 expression contributes to the malignant phenotype of human Neuroblastoma. PMID: 21252912
11. The study indicates that although their mechanisms of regulation may be distinct, both CASZ1b and CASZ1a have largely redundant but critical roles in suppressing tumor cell growth. PMID: 21490919
12. CASZ1 is expressed in a number of human tumors and localizes to a chromosomal region frequently lost in tumors of neuroectodermal origin. PMID: 16631614

Show More

Hide All

HGNC: 26002

OMIM: 609895

KEGG: hsa:54897

STRING: 9606.ENSP00000366221

UniGene: Hs.439894