Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CCAR1 Polyclonal antibody

Uniprot No.

Q8IX12

Target Names

CCAR1

Alternative Names

CARP-1 antibody; Carp1 antibody; Ccar1 antibody; CCAR1_HUMAN antibody; Cell cycle and apoptosis regulatory protein 1 antibody; cell division cycle and apoptosis regulator 1 antibody; Cell division cycle and apoptosis regulator protein 1 antibody; Death inducer with SAP domain antibody; FLJ10590 antibody; FLJ10839 antibody; FLJ13376 antibody; FLJ20734 antibody; MGC7730 antibody; RP11-437A18.1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Cell division cycle and apoptosis regulator protein 1 protein (1-200AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation. May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation. In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells. Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells.

Gene References into Functions

High CCAR1 expression tended to be an independent predictor of shorter recurrence-free survival in hepatocellular carcinoma patients after curative hepatectomy. PMID: 26511806
Our data demonstrates that CCAR1 contributes to carcinogenesis in gastric cancer and is required for the survival of gastric cancer cells. Moreover, CCAR1 may serve as a diagnostic marker and a potential therapeutic target. PMID: 28230774
this study provides insight into the structure and evolution of DBC1 and CCAR1, which may impact future studies on the biological functions of these proteins. PMID: 25610865
necdin exerts its pro-survival activity by counteracting the action of the pro-apoptotic protein Cell Cycle Apoptosis Regulatory Protein (CCAR1/CARP1) PMID: 22905258
CCAR1 is a novel partner of Ngn3 in mediating endocrine differentiation. PMID: 22266316
anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction antagonists are novel regulators of cell growth and apoptosis PMID: 21903591
cell cycle and apoptosis regulatory protein-1 is a novel mediator of apoptosis signaling by retinoid CD437 PMID: 12816952
The study shows that tyrosine 192 of CARP-1 is a target of apoptosis signaling, and CARP-1, in turn, promotes apoptosis by activating p38 MAPK and caspase-9. PMID: 16543231
CARP-1 is a suppressor of breast cancer growth, and its expression is diminished in tumors, in part, by methylation-dependent silencing PMID: 17513614
Damaging exercise induced the expression of capZalpha, MCIP1, CARP1, DNAJB2, c-myc, and junD, each of which are likely involved in skeletal muscle growth, remodeling, and stress management. PMID: 18321953
CCAR1 regulates expression of key proliferation-inducing genes. PMID: 18722177
These results provide the first evidence for the microtubule dependent association of AKAP350A and CCAR1 with RNA stress granules. PMID: 19073175
CCAR1 is a novel component of Wnt/beta-catenin signaling that plays an important role in transcriptional regulation by beta-catenin. PMID: 19520846

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Subcellular Location

Cytoplasm, perinuclear region.

Tissue Specificity

Expressed in various epithelial cancer cell lines, including breast, colon, prostate, pancreatic and leukemia. Expression is regulated by growth factors.

Database Links

HGNC: 24236

OMIM: 612569

KEGG: hsa:55749

STRING: 9606.ENSP00000265872

UniGene: Hs.49853

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Code	CSB-PA816898ESR2HU
Size	US$166
	Order now
Image	Western blot All lanes: CCAR1 antibody at 8μg/ml Lane 1: Hela whole cell lysate Lane 2: PC-3 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 133, 132 kDa Observed band size: 133 kDa
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CCAR1 Antibody

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