CCDC134 Antibody

Code CSB-PA863989EA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA863989EA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA863989EA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CCDC134 Polyclonal antibody
Uniprot No.
Target Names
CCDC134
Alternative Names
CC134_HUMAN antibody; ccdc134 antibody; coiled-coil domain containing 134 antibody; Coiled-coil domain-containing protein 134 antibody; dJ821D11.3 antibody; FLJ22349 antibody; MGC21013 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Coiled-coil domain-containing protein 134 protein (23-229AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The CCDC134 Antibody (Product code: CSB-PA863989EA01HU) is Non-conjugated. For CCDC134 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA863989EB01HU CCDC134 Antibody, HRP conjugated ELISA
FITC CSB-PA863989EC01HU CCDC134 Antibody, FITC conjugated
Biotin CSB-PA863989ED01HU CCDC134 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function. Enhances cytotoxic anti-tumor activity of CD8(+) T cells. May inhibit ERK and JNK signaling activity. May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling.; In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated H3K14 and H4K8 HAT activity. May inhibit TADA2A-mediated TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage.
Gene References into Functions
  1. CCDC134 may also act as a novel regulator of human alteration/deficiency in activation 2a, and be involved in the p300-CBP-associated factor complex and affect its acetyltransferase activity PMID: 29115376
  2. CCDC134 promotes cell proliferation through the JAK3-STAT5 pathway. PMID: 25125657
  3. The attenuated expression of CCDC134 promoted the activation of Erk1/2 and JNK/SAPK, but had no effect on p38 in gastric cancer. PMID: 23070808
  4. CCDC134 might act as a novel regulator of hADA2a, and plays roles in the PCAF complex via hADA2a to affect its acetyltransferase activity and UV-induced DNA damage repair. PMID: 22644376
  5. These results clearly indicate that CCDC134 is a novel member of the secretory family and down-regulates the Raf-1/MEK/ERK and JNK/ SAPK pathways. PMID: 18087676

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Subcellular Location
Nucleus. Cytoplasm. Secreted. Endoplasmic reticulum.
Protein Families
CCDC134 family
Tissue Specificity
Expressed in cervical gland, cervical squamous epithelium, endometrium, stomach, kidney distal convoluted tubule, spermatogenic cells in testis, mammary gland, liver and striated muscle (at protein level). Also detected in placenta. Highest expression in
Database Links

HGNC: 26185

KEGG: hsa:79879

STRING: 9606.ENSP00000255784

UniGene: Hs.474991

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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