CCDC28B Antibody

Code CSB-PA866287LA01HU
Size US$166
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Image
  • IHC image of CSB-PA866287LA01HU diluted at 1:200 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CCDC28B Polyclonal antibody
Uniprot No.
Target Names
CCDC28B
Alternative Names
CCDC28BCoiled-coil domain-containing protein 28B antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Coiled-coil domain-containing protein 28B protein (1-76AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The CCDC28B Antibody (Product code: CSB-PA866287LA01HU) is Non-conjugated. For CCDC28B Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA866287LB01HU CCDC28B Antibody, HRP conjugated ELISA
FITC CSB-PA866287LC01HU CCDC28B Antibody, FITC conjugated
Biotin CSB-PA866287LD01HU CCDC28B Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:200-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in ciliogenesis. Regulates cilia length through its interaction with MAPKAP1/SIN1 but independently of mTORC2 complex. Modulates mTORC2 complex assembly and function, possibly enhances AKT1 phosphorylation. Does not seem to modulate assembly and function of mTORC1 complex.
Gene References into Functions
  1. Findings implicate CCDC28B in the regulation of mTORC2, and uncover a novel function of SIN1 regulating cilia length that is likely independent of mTOR signaling. PMID: 23727834
  2. reports CCDC28B as a novel protein involved in the process of ciliogenesis whilst providing functional insight into the cellular basis of its modifier effect in Bardet-Biedl syndrome. PMID: 23015189
  3. identification of a novel locus, MGC1203, that contributes epistatic alleles to Bardet-Biedl syndrome, a pleiotropic, oligogenic disorder; MGC1203 encodes a pericentriolar protein that interacts and colocalizes with the BBS proteins PMID: 16327777
Involvement in disease
Bardet-Biedl syndrome (BBS)
Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=It localizes near centrosomes and basal bodies.
Database Links

HGNC: 28163

OMIM: 209900

KEGG: hsa:79140

STRING: 9606.ENSP00000362704

UniGene: Hs.534482

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