CCDC28B Antibody

Datasheet
Code CSB-PA866287LA01HU
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Size US$299
Uniprot No. Q9BUN5
Image
  • IHC image of CSB-PA866287LA01HU diluted at 1:200 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunogen Recombinant Human Coiled-coil domain-containing protein 28B protein (1-76AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, IHC; Recommended dilution: IHC:1:200-1:500
Relevance Involved in ciliogenesis. Regulates cilia length through its interaction with MAPKAP1/SIN1 but independently of mTORC2 complex. Modulates mTORC2 complex assembly and function, possibly enhances AKT1 phosphorylation. Does not seem to modulate assembly and function of mTORC1 complex.
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Coiled-coil domain-containing protein 28B, CCDC28B
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Research Area Cell Biology
Target Names CCDC28B
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Involved in ciliogenesis. Regulates cilia length through its interaction with MAPKAP1/SIN1 but independently of mTORC2 complex. Modulates mTORC2 complex assembly and function, possibly enhances AKT1 phosphorylation. Does not seem to modulate assembly and function of mTORC1 complex.
Involvement in disease Bardet-Biedl syndrome (BBS)
Subcellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Database Links

HGNC: 28163

OMIM: 209900

KEGG: hsa:79140

STRING: 9606.ENSP00000362704

UniGene: Hs.534482

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