CCDC8 Antibody

Datasheet

Code	CSB-PA880938LA01HU
Size	US$166
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Image	Immunofluorescent analysis of Hela cells using CSB-PA880938LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) Western Blot Positive WB detected in: Mouse liver tissue All lanes: CCDC8 antibody at 3μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 60 kDa Observed band size: 60 kDa
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CCDC8 Polyclonal antibody

Uniprot No.

Q9H0W5

Target Names

CCDC8

Alternative Names

CCDC8 antibody; CCDC8_HUMAN antibody; Coiled coil domain containing 8 antibody; Coiled-coil domain-containing protein 8 antibody; DKFZp564K0322 antibody; ENSMUSG00000041117 antibody; MGC72567 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Coiled-coil domain-containing protein 8 protein (214-513AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CCDC8 Antibody (Product code: CSB-PA880938LA01HU) is Non-conjugated. For CCDC8 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA880938LB01HU	CCDC8 Antibody, HRP conjugated	ELISA
FITC	CSB-PA880938LC01HU	CCDC8 Antibody, FITC conjugated
Biotin	CSB-PA880938LD01HU	CCDC8 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:2000-1:5000
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Required for localization of CUL7 to the centrosome.

Gene References into Functions

Variants near TTN and CCDC8 were associated with KI67 expression, and rs2288563 and rs2562832 in TTN are potential biomarkers for the prediction of clinical outcomes in hepatitis B-related hepatocellular carcinoma patients. PMID: 28700999
CCDC8 may suppress the invasion and metastasis of non-small cell lung cancer cells. PMID: 27342910
CUL7, OBSL1 and CCDC8 modulate the alternative splicing of the INSR PMID: 24711643
The CUL7, OBSL1, and CCDC8 proteins form a 3M complex that functions in maintaining microtubule and genome integrity and normal development. PMID: 24793695
Mutations in CUL7, OBSL1 and CCDC8 in 3-M syndrome lead to disordered growth factor signalling. PMID: 23018678
discussion of roles of CCDC8, CUL7 (cullin 7), and OBSL1 (obscurin-like 1) in growth and development using findings from patients with Miller-McKusick-Malvaux syndrome and Silver-Russell syndrome [REVIEW] PMID: 22156540
p90 is a critical cofactor for p53-mediated apoptosis through promoting Tip60-mediated p53 acetylation. PMID: 22084066
We propose that CUL7, OBSL1, and CCDC8 are members of a pathway controlling mammalian growth. PMID: 21737058

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Involvement in disease

3M syndrome 3 (3M3)

Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Tissue Specificity

Widely expressed with low levels in spleen, skeletal muscle, small intestine, kidney and liver.

Database Links

HGNC: 25367

OMIM: 614145

KEGG: hsa:83987

STRING: 9606.ENSP00000303158

UniGene: Hs.744359

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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