CCNG1 Antibody

Code CSB-PA203465
Size US$297
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  • Western blot analysis of extracts from Jurkat cells, using Cyclin G antibody.
  • Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using Cyclin G antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CCNG1 Polyclonal antibody
Uniprot No.
Target Names
CCNG1
Alternative Names
CCNG 1 antibody; CCNG antibody; CCNG1 antibody; CCNG1_HUMAN antibody; CYCG1 antibody; Cyclin G antibody; Cyclin G1 antibody; Cyclin-G antibody; Cyclin-G1 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from Human Cyclin G.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
IHC 1:50-1:100
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation.
Gene References into Functions
  1. miR-516b functions as a tumor suppressor by directly modulating CCNG1 expression in esophageal squamous carcinoma cells. PMID: 30119241
  2. Low CCNG1 expression is associated with cancer. PMID: 29787434
  3. Data show that the miR-27b/cyclin G1 protein (CCNG1)/p53 tumor suppressor protein (P53)/miR-508-5p axis plays important roles in gastric cancer (GC)-associated multidrug resistance (MDR). PMID: 26623719
  4. Results show that miR-23b may inhibit epithelial ovarian tumorigenesis and progression by targeting CCNG1 and modulating the expression of the relevant genes. PMID: 26872615
  5. OA induced cell cycle arrest in lung cancer cells through miR-122/Cyclin G1/MEF2D pathway. This finding may contribute to the understanding of the molecular mechanism of OA's anti-tumor activity PMID: 25472877
  6. Progesterone-induced cyclin G1 mediates the inhibitory effect of progesterone on endometrial epithelial cell proliferation. PMID: 25007270
  7. cyclin G1 exerts negative control on proliferation of endometrial carcinoma cells (ECCs). PMID: 23589924
  8. cyclin G1 levels were increased in normal tissue compared with hepatocellular carcinoma tissue and vary over the course of the cell cycle, with equal distribution between the nucleus and cytoplasm. PMID: 22835824
  9. data suggest that the deficiency of progesterone and its receptors is an important cause of the decreased expression of cyclin G1 in endometrial carcinoma, which may account for carcinogenesis and development of endometrial carcinomas PMID: 22649121
  10. Cyclin G1 overexpression enhanced Akt activation through interaction with p85 (regulatory subunit of phosphoinositide 3-kinase) PMID: 22271581
  11. Expression of cyclin G1 and G2 is strongly associated with nasopharyngeal carcinoma cell differentiation. PMID: 21688120
  12. Loss of microRNA 122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G(1) -modulated P53 activity. PMID: 22105316
  13. Low expression of P27(kip1) and the high expression of cyclin G in patients acute leukemia may have some correlation with genesis and development of the disease. PMID: 19698214
  14. cyclin G1 has growth inhibitory activity that is mechanistically linked to ARF-p53 and pRb tumor suppressor pathways. PMID: 12556559
  15. does not increase significantly during colorectal carcinogenesis and during later metastasis to lymph nodes. PMID: 12684677
  16. cyclin G has a role in ATM-dependent p53 regulation and in cell cycle regulation during DNA damage PMID: 15077171
  17. cyclin G1 is a target of miR-122a in human hepatocellular carcinoma PMID: 17616664
  18. the cyclin box has a role in the proteasome-mediated degradation of cyclin G1 PMID: 18632610
  19. The B'alpha1 subunit of the serine/threonine protein phosphatase 2A, which binds to cyclin G1, can stabilize cyclin G1 under unstressed conditions and upon DNA damage, as well as inhibit the ability of cyclin G1 to be ubiquitinated. PMID: 18981217
  20. Results show that in patients resected for HCC, lower miR-122 levels were associated with a shorter TTR, whereas higher cyclin G1 expression was related to a lower survival, suggesting that miR-122 might represent an effective molecular target for HCC. PMID: 19584283

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Subcellular Location
Nucleus. Note=DNA replication foci after DNA damage.
Protein Families
Cyclin family, Cyclin G subfamily
Tissue Specificity
High levels in skeletal muscle, ovary, kidney and colon.
Database Links

HGNC: 1592

OMIM: 601578

KEGG: hsa:900

STRING: 9606.ENSP00000344635

UniGene: Hs.79101

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7505 Fannin St., Ste 610, Room 322 (CUBIO Innovation Center), Houston, TX 77054, USA
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