CCT3 Antibody

Datasheet

Code	CSB-PA004857ESR1HU
Size	US$166
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Image	Western blot All lanes: T-complex protein 1 subunit gamma antibody at 12μg/ml + Mouse brain tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 61, 57 kDa Observed band size: 61 kDa Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA004857ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA004857ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CCT3 Polyclonal antibody

Uniprot No.

P49368

Target Names

CCT3

Alternative Names

CCT 3 antibody; CCT gamma antibody; CCT-gamma antibody; CCT3 antibody; CCTG antibody; Chaperonin containing TCP1 subunit 3 (gamma) antibody; Chaperonin containing TCP1 subunit 3 antibody; hTRiC5 antibody; PIG48 antibody; T complex protein 1 gamma subunit antibody; T complex protein 1 subunit gamma antibody; T-complex protein 1 subunit gamma antibody; TCP 1 gamma antibody; TCP-1-gamma antibody; TCP1 (t complex 1) ring complex polypeptide 5 antibody; TCPG_HUMAN antibody; TRIC5 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human T-complex protein 1 subunit gamma protein (1-300AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.

Gene References into Functions

Suggest that CCT3 is indispensible for hepatocellular carcinoma cell proliferation, and provides a potential drug target for treatment of HCC. PMID: 26739059
Overexpression of CCT3 in the nuclei of cancerous cells is associated with hepatocellular carcinoma progression. CCT3 may be a target that affects the activation of STAT3 in HCC. PMID: 26229401
Expression of S100A9 and CCTgamma was significantly elevated in liver tissue of patients with cholangiocarcinoma compared with controls. PMID: 23868055
Among ten hepatocellular carcinoma cases with amplicon 1q21-q22, significant gene expression level of JTB, SHC1, CCT3 and COPA in the tumors than the paired adjacent non-malignant liver tissues. PMID: 12586295

Subcellular Location

Cytoplasm.

Protein Families

TCP-1 chaperonin family

Database Links

HGNC: 1616

OMIM: 600114

KEGG: hsa:7203

STRING: 9606.ENSP00000295688

UniGene: Hs.491494

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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