CD1B Antibody

1. polyclonal germline-encoded mycolyl lipid-reactive T cell receptors that recognize CD1b-glucose-6-O-monomycolate use relatively conserved molecular mechanisms PMID: 27807341
2. the development of polyvalent complexes of CD1b proteins and carbohydrate backbones (dextramers) and their use in identifying CD1b autoreactive T cells from human donors. PMID: 26621732
3. for isoforms CD1b through CD1e, our simulations show the near-complete collapse of the hydrophobic cavities in the absence of the antigen. This event results from the spontaneous closure of the binding domain entrance, flanked by two alpha-helices. PMID: 23677998
4. Molecular mechanisms by which CD1b captures distinct classes of self- and mycobacterial antigens are reviewed. Review. PMID: 23468110
5. Deciphering the role of CD1e protein in mycobacterial phosphatidyl-myo-inositol mannosides (PIM) processing for presentation by CD1b to T lymphocytes PMID: 22782895
6. CD1b has a mechanism for presenting either two small or one large lipid, allowing presentation of antigens with an unusually broad range of chain lengths. PMID: 22087000
7. a cognate mechanism whereby CD1b-glycolipid complexes bind to TCRs. PMID: 21807869
8. The DC-SIGNlow/CD86high population is characterized by a reduced CD1b expression that correlates with a reduced iMtb-specific lymphocyte proliferation together with an enhanced mixed leukocyte reaction. PMID: 20212510
9. gammadelta T cells recognize lipid A (LA) in a CD1b- or CD1c-restricted manner in first response against Gram-bacteria, while the interaction between TLR4 on gammadelta T cells and LA might strengthen the subsequent response of gammadelta T cells. PMID: 19948070
10. Lipid length controls antigen entry into endosomal and nonendosomal pathways for CD1b presentation. PMID: 11938350
11. Failure of trafficking and antigen presentation by CD1b in AP-3-deficient cells PMID: 12049721
12. CD1b and CD1c show strong binding of nitrobenzoxadiazole (NBD)-labeled dialkyl-based ligands. PMID: 14551186
13. model proposed in which saposin C exposes lipid antigens from intralysosomal membranes for loading onto CD1b PMID: 14716313
14. Current crystal structure illustrates for the first time the binding of a natural bacterial lipid antigen to CD1b and shows how its novel structural features fit the CD1b molecule for its role in the immune response to intracellular bacteria. PMID: 14764708
15. CD1b expression was detected on monocytes in the majority of sickle cell anemia patients, and was highly expressed in Sbeta thalassemia patients. PMID: 15556687
16. Expression of DC-SIGN and CD1b in human leprosy. PMID: 15880118
17. Endosomal acidification acts directly, rather than through enzymatic trimming, to insert lipids into CD1b. PMID: 16794581
18. The data presented herein explain how the CD1b groove is preserved, and provide a rationale for the in vivo antigen-binding properties of CD1b. PMID: 16874306
19. study proposes that ionic tethers act as molecular switches that respond to pH fluxes during endosomal recycling and regulate the conformation of the CD1 heavy chain to control the size and rate of antigens captured PMID: 18538591
20. The crystal structure of an avian CD1 (chCD1-2) that shares common ancestry with mammalian CD1 from approximately 310 million years ago, was determined. PMID: 19004781
21. mycobacterial lipids structural constraints governing binding to CD1b and generation of antigenic CD1b:lipid PMID: 19454700
22. Group 1 CD1-restricted T cells participate in adaptive immune responses upon mycobacterial infection. PMID: 19808251

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HGNC: 1635

OMIM: 188360

KEGG: hsa:910

STRING: 9606.ENSP00000357150

UniGene: Hs.1310