Product Details

Uniprot No.

Target Names

Alternative Names

CD_antigen=CD84 antibody; CD84 antibody; CD84 antigen antibody; CD84 molecule antibody; CDw84 antibody; Cell surface antigen MAX.3 antibody; hCD84 antibody; Hly9 beta antibody; Hly9-beta antibody; Leucocyte differentiation antigen CD84 antibody; Leukocyte Antigen antibody; Leukocyte antigen CD84 antibody; Leukocyte differentiation antigen antibody; Leukocyte differentiation antigen CD84 antibody; LY9B antibody; mCD84 antibody; Signaling lymphocytic activation molecule 5 antibody; SLAF5_HUMAN antibody; SLAM family member 5 antibody; SLAMF5 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthesized peptide derived from the Internal region of Human CD84.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:20000

Protocols

Western Blotting(WB) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway. May serve as a marker for hematopoietic progenitor cells Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation. In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity. In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1. In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2. Positively regulates macroautophagy in primary dendritic cells via stabilization of IRF8; inhibits TRIM21-mediated proteasomal degradation of IRF8.

Gene References into Functions

Results show that CD84 expressed on CLL cells interact with CD84 expressed on cells in their microenvironment, inducing cell survival in both sides. PMID: 27452524
up-regulated in Kawasaki disease arteriopathy PMID: 24635044
data show that overexpression of CD84 in CLL is an important survival mechanism that appears to be an early event in the pathogenesis of the disease PMID: 23435417
These findings support a model in which CD84 genotypes and/or expression may serve as a useful biomarker for response to etanercept treatment in RA patients of European ancestry PMID: 23555300
CD84 is highly expressed in mast cells and that it contributes to the regulation of FcepsilonRI signaling PMID: 22068234
CD84 enhances proliferation of human activated T cells by a Src homology 2 domain-containing cytoplasmic adaptor protein SLAM-associated protein (SAP)-independent mechanism. PMID: 12928397
The structure of CD84 provides insight into SLAM family function. Point mutations were studied. PMID: 17563375
These data suggest that CD84 may play a role in modulating Fc epsilon RI-mediated signaling in mast cells. PMID: 18243321

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Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Tissue Specificity

Predominantly expressed in hematopoietic tissues, such as lymph node, spleen and peripheral leukocytes. Expressed in macrophages, B-cells, monocytes, platelets, thymocytes, T-cells and dendritic cells. Highly expressed in memory T-cells. Expressed in mast

Database Links

HGNC: 1704

OMIM: 604513

KEGG: hsa:8832

STRING: 9606.ENSP00000312367

UniGene: Hs.398093

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Code	CSB-PA005235
Size	US$119
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Image	Western Blot analysis of K562 L929 cells using CD84 Polyclonal Antibody
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CD84 Antibody

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Target Background