CD84

CD84, also known as Cluster of Differentiation 84, is a membrane glycoprotein belonging to the SLAM family. It is predominantly expressed on immune cells and plays a crucial role in immune regulation. CD84 interacts with SAP and EAT-2 adaptors, modulating T cell activation and differentiation. The protein is involved in various immune processes, including NK cell cytotoxicity, T cell proliferation, and B cell tolerance. CD84 has been implicated in diseases such as Kawasaki disease and multiple myeloma, where it contributes to inflammation and immune dysregulation. Research on CD84 signaling pathways may lead to novel therapeutic strategies for these conditions.