CDK5RAP3 Antibody

1. CDK5RAP3 negatively regulates the beta-catenin signaling pathway by repressing GSK-3beta phosphorylation in gastric neoplasms. PMID: 27793695
2. C53/LZAP protein bound indirectly to the microtubule (MT), and expression of the C53/LZAP cleavage product caused abnormal MT bundling and NE rupture. PMID: 23478299
3. our findings provide the new evidence that overexpression of CDK5RAP3 promotes HCC metastasis via downregulation of p14(ARF). PMID: 22860085
4. LZAP may play an important role in hepatocellular carcinoma progression PMID: 22028922
5. our results strongly suggest that the binding of hepatitis viral pre-S2 LHBs with C53 is a novel negative regulator of the checkpoint response PMID: 21971960
6. Data indicate that IC53 is a positive mediator for colon cancer progression, and IC53-rs2737 may serve as protection from the onset of colorectal cancer. PMID: 21394385
7. Nuclear gamma-tubulin interacts with tumor suppressor protein C53 that is involved in regulation of DNA damage PMID: 21465471
8. the ability of LZAP to alter p38 phosphorylation depended, at least partially, on the p38 phosphatase, Wip1 PMID: 21283629
9. Findings reveal that CDK5RAP3 is widely overexpressed in hepatocellular carcinoma and that overexpression of CDK5RAP3 promotes HCC metastasis through PAK4 activation. PMID: 21385901
10. IC53 is a novel gene, mainly expressed in vascular endothelial cells and mediates cell proliferation PMID: 12054757
11. results strongly indicate that in response to genotoxic stress, Cdk5 activator-binding protein C53(C53) serves as an important regulatory component of DNA damage checkpoint through modulating cyclin dependent kinase 1-cyclin B1 function PMID: 15790566
12. It is suggested that LZAP can regulate ARF biochemical and biological activity; additionally, LZAP has p53-dependent cell-cycle effects that are independent of ARF. PMID: 16173922
13. it is concluded that CDK5RAP3, CCNB2, and RAGE genes may be used as a very reliable biomarkers of lung adenocarcinoma PMID: 17549666
14. LZAP has a role in NF-kappaB regulation and tumor suppression. PMID: 17785205
15. CDK5 regulatory subunit associated protein 3 promotes checkpoint kinase 1 activation and mitotic entry in both unperturbed cell-cycle progression and DNA damage response. PMID: 19223857
16. Endothelium-specific overexpression of human IC53 downregulates endothelial nitric oxide synthase activity and elevates systolic blood pressure in mice. PMID: 19541669

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HGNC: 18673

OMIM: 608202

KEGG: hsa:80279

STRING: 9606.ENSP00000344683

UniGene: Hs.20157