CDNF Antibody

1. Polymorphisms in CDN,F identified in a Han Chinese population, were associated with increased susceptibility to schizophrenia. PMID: 29298719
2. In various animal models of Parkinson Disease, CDNF is efficient in protecting and repairing dopaminergic neurons, and it inhibits endoplasmic reticulum stress, euroinflammation, and apoptosis. PMID: 28337696
3. The results showed that AAV8-CDNF administration significantly improved the motor function and increased the tyrosine hydroxylase (TH) levels in Parkinson's disease rats with mild lesions (2 weeks post lesion), but it had limited therapeutic effects in rats with severe lesions (5 weeks post lesion). PMID: 28622392
4. Results suggest that CDNF treatment selectively enhances long-term memory consolidation PMID: 25975173
5. showed that CDNF was able to protect dopaminergic neurons against injury caused by alpha-synuclein oligomers. This advises its use against physiological damages caused by alpha-synuclein oligomers PMID: 26149686
6. Expression of CDNF in the substantia nigra has an anti-inflammatory effect on experimental Parkinson's disease. PMID: 25511018
7. Although no CDNF mutations are found in early-onset Parkinson's disease patient samples, a trend towards increased risk for Parkinson's in carriers of the C allele of rs7094179 single nucleotide polymorphism (SNP) is found. PMID: 21320571
8. expressed in several tissues; might be beneficial for the treatment of Parkinson's disease PMID: 17611540
9. structures of MANF and CDNF were solved; structure explains why MANF and CDNF are bifunctional; neurotrophic activity may reside in the N-terminal domain and ER stress response in the C-terminal domain PMID: 19258449
10. Study suggests that there is no association between variants in the CDNF gene and cocaine dependence. PMID: 19429035
11. Observational study of gene-disease association. (HuGE Navigator) PMID: 19429035

Show More

Hide All

HGNC: 24913

OMIM: 611233

KEGG: hsa:441549

STRING: 9606.ENSP00000419395

UniGene: Hs.559067