CELSR1 Antibody

Datasheet

Code	CSB-PA868360NA01HU
Size	US$166
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Image	IHC image of CSB-PA868360NA01HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CELSR1 Polyclonal antibody

Uniprot No.

Q9NYQ6

Target Names

CELSR1

Alternative Names

CELSR1 antibody; CDHF9 antibody; FMI2Cadherin EGF LAG seven-pass G-type receptor 1 antibody; Cadherin family member 9 antibody; Flamingo homolog 2 antibody; hFmi2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Peptide sequence from Human Cadherin EGF LAG seven-pass G-type receptor 1 protein (345-363AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CELSR1 Antibody (Product code: CSB-PA868360NA01HU) is Non-conjugated. For CELSR1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA868360NB01HU	CELSR1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA868360NC01HU	CELSR1 Antibody, FITC conjugated
Biotin	CSB-PA868360ND01HU	CELSR1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Receptor that may have an important role in cell/cell signaling during nervous system formation.

Gene References into Functions

Patients with CELSR1 mutations and spina bifida can have significant renal malformations. PMID: 27597235
This single-nucleotide polymorphism-by-sex genome-wide association analysis identified the fetal lung development gene, CELSR1, as a potential sex-specific risk factor for Chronic obstructive pulmonary disease. PMID: 27854507
Upregulating CELSR1 expression significantly promoted cell growth, while knocking down CELSR1 inhibited the growth and decreased tube formation. PMID: 27301287
Single nucleotide polymorphisms in nNOS, renalase, MTHFR, CELSR1 and XYLB genes were found significantly associated with ischemic stroke in Chinese patients. PMID: 25855559
the present study has proven for the first time that CELSR1 is a susceptibility gene for ischaemic stroke in the Chinese Han population, especially for large artery atherosclerosis. PMID: 25117632
CELSR1 mutations contribute to the risk of spina bifida in a cohort of spina bifida patients from California PMID: 24632739
Celsr1 regulates dynamic cell movements by inhibiting stabilization of VE-cadherin and maturation of adherens junctions. PMID: 23792146
CELSR1 is a risk factor for neural tube defects or caudal agenesis via pathogenic role of planar cell polarity signaling in these malformations. PMID: 22371354
Missense variants in CELSR1 may represent a cause of craniorachischisis in humans, as in mice, with defective planar cell polarity protein trafficking to the plasma membrane a likely pathogenic mechanism. PMID: 22095531
CELSR1 may have a role in ischemic stroke, as shown in a Portuguese case-control cohort PMID: 21511255
The planar cell polarity genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis. PMID: 20223754
Identification of CELSR1 as a susceptibility gene for ischemic stroke in Japanese individuals by a genome-wide association study. PMID: 19403135
exclusion as a candidate gene for schizophrenia-- a cadhrin gene PMID: 11807409
Variations in the nine ectodomains of CELSR1 do not increase susceptibility to schizophrenia. PMID: 12782967

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Involvement in disease

Neural tube defects (NTD)

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

G-protein coupled receptor 2 family, LN-TM7 subfamily

Database Links

HGNC: 1850

OMIM: 182940

KEGG: hsa:9620

STRING: 9606.ENSP00000262738

UniGene: Hs.252387

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Protein Service

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Related pathways

G protein coupled receptor signaling pathway

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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