CELSR2 Antibody

Code CSB-PA007949
Size US$100
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Product Details

Uniprot No.
Target Names
CELSR2
Alternative Names
Cadherin EGF LAG seven pass G type receptor 2 flamingo Drosophila homolog antibody; Cadherin EGF LAG seven-pass G-type receptor 2 antibody; Cadherin family member 10 antibody; CDHF10 antibody; CELR2_HUMAN antibody; Celsr2 antibody; EGF like domain multiple 2 antibody; EGF-like protein 2 antibody; EGFL2 antibody; epidermal growth factor like 2 antibody; Epidermal growth factor-like protein 2 antibody; Flamingo homolog 3 antibody; Flamingo1 antibody; KIAA0279 antibody; MEGF3 antibody; Multiple EGF-like domains protein 3 antibody; Multiple epidermal growth factor-like domains 3 antibody; Multiple epidermal growth factor-like domains protein 3 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the C-terminal region of Human CDHF10.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
IHC, IF, ELISA
Recommended Dilution
Application Recommended Dilution
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Receptor that may have an important role in cell/cell signaling during nervous system formation.
Gene References into Functions
  1. Both CELSR2 and ING4 display increased cytoplasmic staining in breast cancer cells compared to benign epithelium, suggesting a possible role of both genes in the pathogenesis of human mammary neoplasia. PMID: 29489009
  2. findings suggest a rare variant in CELSR2 as causative for idiopathic scoliosis in a family with dominant segregation and further highlight common variation in CELSR2 in general susceptibility to idiopathic scoliosis in the Swedish-Danish population PMID: 29240829
  3. we report bi-allelic mutations in CELSR2 in a Joubert patient with cortical heterotopia, microophthalmia, and growth hormone deficiency. PMID: 28052552
  4. no association was found between the SNPs of rs599839, rs464218 and rs6698843 at the CELSR2-PSRC1-SORT1 and the risk of coronary artery disease or ischemic stroke PMID: 26464717
  5. CELSR2 in the cholesterol gene cluster shows a significant association with coronary artery disease and its single nucleotide polymorphism regulates plasma cholesterol levels. PMID: 24674750
  6. The novel CAD-associated locus in the vicinity of the PSRC1 and CELSR2 genes on chromosome 1 probably enhances CAD risk through an effect on plasma LDL cholesterol. PMID: 18649068

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 2 family, LN-TM7 subfamily
Tissue Specificity
Highest expression in brain and testis.
Database Links

HGNC: 3231

OMIM: 604265

KEGG: hsa:1952

STRING: 9606.ENSP00000271332

UniGene: Hs.57652

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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