CEP135 Antibody, FITC conjugated

Datasheet

Code	CSB-PA721063LC01HU
Size	US$166
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CEP135 Polyclonal antibody

Uniprot No.

Q66GS9

Target Names

CEP135

Alternative Names

centrosomal protein 135 kDa antibody; centrosomal protein 135kDa antibody; Centrosomal protein 4 antibody; Centrosomal protein of 135 kDa antibody; centrosome protein 4 antibody; centrosome protein cep135 antibody; Cep135 antibody; CEP4 antibody; CP135_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Centrosomal protein of 135 kDa protein (94-195AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner.

Gene References into Functions

CEP135 segment 96-108 is a major microtubule-binding site. PMID: 27477386
identified the second mutation in CEP135, confirming the role during embryonic brain development and in the pathophysiology of human primary microcephaly PMID: 26657937
Authors suggest that the decrease in CEP135(mini) from centrosomes promotes centriole assembly. The repression of centriole duplication by a splice isoform of a protein that normally promotes it serves as a novel mechanism to limit centriole duplication. PMID: 26412126
These findings support a model in which PKC-mediated phosphorylation of CEP4 at Ser(18) and Ser(80) causes its dissociation from Cdc42, thereby increasing its affinity for TEM4 and producing Rac activation, filopodium formation, and cell motility PMID: 25086031
Authors propose that CEP135 directly connects the central hub protein, hSAS-6, to the outer microtubules, and suggest that this interaction stabilizes the proper cartwheel structure for further CPAP-mediated centriole elongation. PMID: 23511974
A truncating mutation of CEP135 caused autosomal-recessive primary microcephaly in a Pakistani family. PMID: 22521416
CEP135 acts as a platform protein for C-NAP1 at the centriole. PMID: 18851962

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Involvement in disease

Microcephaly 8, primary, autosomal recessive (MCPH8)

Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=During centriole biogenesis, it is concentrated within the proximal lumen of both parental centrioles and procentrioles.

Protein Families

CEP135/TSGA10 family

Database Links

HGNC: 29086

OMIM: 611423

KEGG: hsa:9662

STRING: 9606.ENSP00000257287

UniGene: Hs.518767

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