CFHR2 Antibody, HRP conjugated

Code CSB-PA13817B0Rb
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CFHR2 Polyclonal antibody
Uniprot No.
Target Names
CFHR2
Alternative Names
CFHL2 antibody; CFHR2 antibody; Complement factor H related protein 2 antibody; Complement factor H-related 2 antibody; Complement factor H-related protein 2 antibody; DDESK59 antibody; Factor H-related gene 2 antibody; FHR 2 antibody; FHR-2 antibody; FHR2 antibody; FHR2_HUMAN antibody; H factor (complement)-like 3 antibody; H factor like 3 antibody; H factor like protein 2 antibody; H factor-like 3 antibody; H factor-like protein 2 antibody; HFL3 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Complement factor H-related protein 2 protein (20-269AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism.
Gene References into Functions
  1. Studies indicate an association between CFHR2-rs2986127 and acute anterior uveitis (AAU) diagnosis. PMID: 27306586
  2. Next-generation sequencing of the CFH region identified putatively functional variants (missense, splice site and indel) on the four common haplotypes. We found no expression of any of the five CFH-related genes in the retina or RPE/Choroid/Sclera, in contrast to the liver, which is the main source of the circulating proteins. [CFHR2] PMID: 27196323
  3. Thus CFHR2 likely acts in concert with factor H, as CFHR2 inhibits convertases while simultaneously allowing factor H assisted degradation by factor I. PMID: 24260121
  4. A hybrid CFHR2-CFHR5 plasma protein, arising from a chromosomal deletion mutation stabilizes the C3 convertase and reduces factor H-mediated convertase decay. PMID: 24334459
Subcellular Location
Secreted.
Tissue Specificity
Expressed by the liver and secreted in plasma.
Database Links

HGNC: 4890

OMIM: 600889

KEGG: hsa:3080

STRING: 9606.ENSP00000356385

UniGene: Hs.632450

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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