CFHR2 Antibody

Datasheet

Code	CSB-PA13817A0Rb
Size	US$166
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Image	Western blot All lanes: CFHR2 antibody at 2µg/ml Lane 1: Hela whole cell lysate Lane 2: 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 31, 28 kDa Observed band size: 36 kDa Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA13817A0Rb at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CFHR2 Polyclonal antibody

Uniprot No.

P36980

Target Names

CFHR2

Alternative Names

CFHL2 antibody; CFHR2 antibody; Complement factor H related protein 2 antibody; Complement factor H-related 2 antibody; Complement factor H-related protein 2 antibody; DDESK59 antibody; Factor H-related gene 2 antibody; FHR 2 antibody; FHR-2 antibody; FHR2 antibody; FHR2_HUMAN antibody; H factor (complement)-like 3 antibody; H factor like 3 antibody; H factor like protein 2 antibody; H factor-like 3 antibody; H factor-like protein 2 antibody; HFL3 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Complement factor H-related protein 2 protein (20-269AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CFHR2 Antibody (Product code: CSB-PA13817A0Rb) is Non-conjugated. For CFHR2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA13817B0Rb	CFHR2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA13817C0Rb	CFHR2 Antibody, FITC conjugated
Biotin	CSB-PA13817D0Rb	CFHR2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism.

Gene References into Functions

Studies indicate an association between CFHR2-rs2986127 and acute anterior uveitis (AAU) diagnosis. PMID: 27306586
Next-generation sequencing of the CFH region identified putatively functional variants (missense, splice site and indel) on the four common haplotypes. We found no expression of any of the five CFH-related genes in the retina or RPE/Choroid/Sclera, in contrast to the liver, which is the main source of the circulating proteins. [CFHR2] PMID: 27196323
Thus CFHR2 likely acts in concert with factor H, as CFHR2 inhibits convertases while simultaneously allowing factor H assisted degradation by factor I. PMID: 24260121
A hybrid CFHR2-CFHR5 plasma protein, arising from a chromosomal deletion mutation stabilizes the C3 convertase and reduces factor H-mediated convertase decay. PMID: 24334459

Subcellular Location

Secreted.

Tissue Specificity

Expressed by the liver and secreted in plasma.

Database Links

HGNC: 4890

OMIM: 600889

KEGG: hsa:3080

STRING: 9606.ENSP00000356385

UniGene: Hs.632450

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Target Therapy

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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