CGN Antibody

Datasheet

Code	CSB-PA005302LA01HU
Size	US$166
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Image	IHC image of CSB-PA005302LA01HU diluted at 1:800 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CGN Polyclonal antibody

Uniprot No.

Q9P2M7

Target Names

CGN

Alternative Names

6330408J11Rik antibody; AI647528 antibody; AI987749 antibody; cgn antibody; CING_HUMAN antibody; Cingulin antibody; DKFZp779N1112 antibody; FLJ39281 antibody; KIAA1319 antibody; MGC118157 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Cingulin protein (92-252AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CGN Antibody (Product code: CSB-PA005302LA01HU) is Non-conjugated. For CGN Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA005302LB01HU	CGN Antibody, HRP conjugated	ELISA
FITC	CSB-PA005302LC01HU	CGN Antibody, FITC conjugated
Biotin	CSB-PA005302LD01HU	CGN Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:500-1:1000

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.

Gene References into Functions

Down-regulation of Cingulin Augments Thrombin-induced Endothelial Barrier Disruption. PMID: 27590342
Cingulin modulates barrier function in endothelium. PMID: 26821949
MgcRacGAP colocalizes with CGN and CGNL1 at TJs and forms a complex and interacts directly in vitro with CGN and CGNL1. PMID: 24807907
Co-imunoprecipitation and confocal microscopy experiments also revealed the tight junction protein cingulin as a new interacting partner of Ubn-1 PMID: 22245583
Results indicate that cells underwent EMT exhibited overactive TGFbeta signaling and loss of expression of the CDH1, CGN, CLDN4, and KLK10 genes as a result of hypermethylation of their corresponding promoter regions. PMID: 20086175
Cingulin (KIAA1319 protein) is localized in the cytoplasmic domain of vertebrate epithelial tight junctions, and it interacts with other tight junction proteins such as ZO-1, and with the actomyosin cytoskeleton. PMID: 11042084

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Subcellular Location

Cell junction, tight junction.

Protein Families

Cingulin family

Tissue Specificity

Localized on the cytoplasmic face of tight junctions of polarized epithelia and some endothelia. Expressed in pancreas, kidney, liver and lung, but not in skeletal muscle, placenta, brain or heart.

Database Links

HGNC: 17429

OMIM: 609473

KEGG: hsa:57530

STRING: 9606.ENSP00000271636

UniGene: Hs.591464

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Service

Phage Display Service

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Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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