CHMP7 Antibody

Code CSB-PA855478LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA855478LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CHMP7 Polyclonal antibody
Uniprot No.
Target Names
CHMP7
Alternative Names
CHMP7Charged multivesicular body protein 7 antibody; Chromatin-modifying protein 7 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Charged multivesicular body protein 7 protein (1-290AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The CHMP7 Antibody (Product code: CSB-PA855478LA01HU) is Non-conjugated. For CHMP7 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA855478LB01HU CHMP7 Antibody, HRP conjugated ELISA
FITC CSB-PA855478LC01HU CHMP7 Antibody, FITC conjugated
Biotin CSB-PA855478LD01HU CHMP7 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway.
Gene References into Functions
  1. We conclude that Lem2p/LEM2 is a conserved nuclear site-specific adaptor that recruits Cmp7p/CHMP7 and downstream ESCRT factors to the nuclear envelope. PMID: 28242692
  2. The N terminus of CHMP7 acts as a novel membrane-binding module. This membrane-binding ability allows CHMP7 to bind to the endoplasmic reticulum, an organelle continuous with the nuclear envelope (NE), and it provides a platform to direct NE recruitment of ESCRT-III during mitotic exit. PMID: 27618263
  3. Results suggest that CHMP7, a novel CHMP4-associated ESCRT-III-related protein, functions in the endosomal sorting pathway. PMID: 16856878
Subcellular Location
Cytoplasm. Nucleus envelope.
Protein Families
SNF7 family
Database Links

HGNC: 28439

OMIM: 611130

KEGG: hsa:91782

STRING: 9606.ENSP00000324491

UniGene: Hs.5019

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