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CHPF Antibody

Datasheet
Code CSB-PA445330
Size US$297
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Image
  • Western blot analysis of extracts from LOVO cells and K562 cells, using CHSS2 antibody.
  • Immunohistochemistry analysis of paraffin-embedded human cervix carcinoma tissue using CHSS2 antibody.
  • Immunofluorescence analysis of MCF-7 cells, using CHSS2 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CHPF Polyclonal antibody
Uniprot No.
Q8IZ52
Target Names
CHPF
Alternative Names
CHPF antibody; CSS2 antibody; UNQ651/PRO1281Chondroitin sulfate synthase 2 antibody; EC 2.4.1.175 antibody; EC 2.4.1.226 antibody; Chondroitin glucuronyltransferase 2 antibody; Chondroitin-polymerizing factor antibody; ChPF antibody; Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II antibody; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase II antibody; N-acetylgalactosaminyltransferase 2 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from internal of Human CHSS2.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB,IHC,IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
IHC 1:50-1:100
IF 1:100-1:500
Protocols
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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CHPF Antibodies

CHPF Proteins

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Target Background

Function
Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Isoform 2 may facilitate PRKN transport into the mitochondria. In collaboration with PRKN, isoform 2 may enhance cell viability and protect cells from oxidative stress.
Gene References into Functions
  1. High CHPF expression is associated with gliomas. PMID: 28627702
  2. data suggest that TGF-beta stimulated the expression of ChPF and sGAG synthesis in nucleus pulposus cells through Smad3, RhoA/ROCK1 and the three MAPK signaling pathways. PMID: 28608941
  3. CHPF was found to be differentially methylated in human squamous cell carcinomas. PMID: 22461910
  4. study reports a novel protein named Klokin 1(a splice variant of chondroitin polymerizing factor) that transports Parkin to the mitochondria; findings indicate that mitochondrial Parkin prevents mitochondrial depolarization and that Klokin 1 may compensate for Parkin deficiency PMID: 22082830
  5. Chondroitin sulfate synthase-2/chondroitin polymerizing factor has two variants with distinct function PMID: 20729547
  6. chondroitin polymerizing activity requires concomitant expression of a ChPF with ChSy; coexpression of the ChPF and ChSy yielded markedly augmented glycosyltransferase activities, whereas simple mixing of the two separately expressed proteins did not. PMID: 12716890

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Subcellular Location
[Isoform 1]: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Cytoplasm, cytosol.; [Isoform 3]: Cytoplasm, cytosol. Mitochondrion.; [Isoform 2]: Mitochondrion matrix.
Protein Families
Chondroitin N-acetylgalactosaminyltransferase family
Tissue Specificity
Ubiquitous. Highly expressed in pancreas, ovary, brain, heart, skeletal muscle, colon, kidney, liver, stomach, spleen and placenta. Isoform 3 is also ubiquitous. Isoform 2 is expressed in brain, spleen, ovary, testis, lung and peripheral mononuclear cells
Database Links

HGNC: 24291

OMIM: 610405

KEGG: hsa:79586

STRING: 9606.ENSP00000243776

UniGene: Hs.516711

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