CHRND Antibody, FITC conjugated

Code CSB-PA005399LC01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) CHRND Polyclonal antibody
Uniprot No. Q07001
Target Names CHRND
Alternative Names Acetylcholine receptor delta subunit antibody; Acetylcholine receptor subunit delta antibody; ACHD_HUMAN antibody; ACHRD antibody; Cholinergic receptor, nicotinic, delta polypeptide antibody; CHRND antibody; CMS2A antibody; FCCMS antibody; Nicotinic acetylcholine receptor delta polypeptide precursor antibody; SCCMS antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Acetylcholine receptor subunit delta protein (334-471AA)
Immunogen Species Homo sapiens (Human)
Conjugate FITC
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Gene References into Functions
  1. Data suggest mutation in invariant Cys-loop of CHRND (D140N) observed in muscle of one patient (11 y/o girl) with congenital myasthenia (w/ severe muscle weakness) alters conformation of ligand/acetylcholine binding site and receptor functionality. PMID: 26698174
  2. This study showed that a single mutation of the delta subunit, L332P, allows the synapse in slow muscles to function but renders those in fast muscles almost nonfunctional. PMID: 25080583
  3. Results describe the effects of a point mutation in the AChR delta subunit from a congenital myasthenia patient. PMID: 18398509
Involvement in disease Multiple pterygium syndrome, lethal type (LMPS); Myasthenic syndrome, congenital, 3A, slow-channel (CMS3A); Myasthenic syndrome, congenital, 3B, fast-channel (CMS3B); Myasthenic syndrome, congenital, 3C, associated with acetylcholine receptor deficiency (CMS3C)
Subcellular Location Cell junction, synapse, postsynaptic cell membrane, Multi-pass membrane protein, Cell membrane, Multi-pass membrane protein
Protein Families Ligand-gated ion channel (TC 1.A.9) family, Acetylcholine receptor (TC 1.A.9.1) subfamily, Delta/CHRND sub-subfamily
Database Links

HGNC: 1965

OMIM: 100720

KEGG: hsa:1144

STRING: 9606.ENSP00000258385

UniGene: Hs.156289

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