CHRND Antibody

Datasheet

Code	CSB-PA005399LA01HU
Size	US$166
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Image	Immunofluorescence staining of Hela cells with CSB-PA005399LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CHRND Polyclonal antibody

Uniprot No.

Q07001

Target Names

CHRND

Alternative Names

Acetylcholine receptor delta subunit antibody; Acetylcholine receptor subunit delta antibody; ACHD_HUMAN antibody; ACHRD antibody; Cholinergic receptor, nicotinic, delta polypeptide antibody; CHRND antibody; CMS2A antibody; FCCMS antibody; Nicotinic acetylcholine receptor delta polypeptide precursor antibody; SCCMS antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Acetylcholine receptor subunit delta protein (334-471AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CHRND Antibody (Product code: CSB-PA005399LA01HU) is Non-conjugated. For CHRND Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA005399LB01HU	CHRND Antibody, HRP conjugated	ELISA
FITC	CSB-PA005399LC01HU	CHRND Antibody, FITC conjugated
Biotin	CSB-PA005399LD01HU	CHRND Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IF

Recommended Dilution

Application	Recommended Dilution
IF	1:50-1:200

Protocols

ELISA Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Gene References into Functions

Data suggest mutation in invariant Cys-loop of CHRND (D140N) observed in muscle of one patient (11 y/o girl) with congenital myasthenia (w/ severe muscle weakness) alters conformation of ligand/acetylcholine binding site and receptor functionality. PMID: 26698174
This study showed that a single mutation of the delta subunit, L332P, allows the synapse in slow muscles to function but renders those in fast muscles almost nonfunctional. PMID: 25080583
Results describe the effects of a point mutation in the AChR delta subunit from a congenital myasthenia patient. PMID: 18398509

Involvement in disease

Multiple pterygium syndrome, lethal type (LMPS); Myasthenic syndrome, congenital, 3A, slow-channel (CMS3A); Myasthenic syndrome, congenital, 3B, fast-channel (CMS3B); Myasthenic syndrome, congenital, 3C, associated with acetylcholine receptor deficiency (CMS3C)

Subcellular Location

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Protein Families

Ligand-gated ion channel (TC 1.A.9) family, Acetylcholine receptor (TC 1.A.9.1) subfamily, Delta/CHRND sub-subfamily

Database Links

HGNC: 1965

OMIM: 100720

KEGG: hsa:1144

STRING: 9606.ENSP00000258385

UniGene: Hs.156289

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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