CHSY1 Antibody

1. CHSY1 overexpression in HCC contributes to the malignant behavior of hepatocellular carcinoma cells via activation of the hedgehog signaling pathway. PMID: 28652022
2. CHSY1 expression is closely associated with malignant potential of soft tissue sarcomas with myxoid substance. PMID: 26997434
3. A novel missense mutation (c.1897 G > A) in the CHSY1 gene in two Temtamy preaxial brachydactyly syndrome patients from a consanguineous Pakistani family. PMID: 24269551
4. elongation of chondroitin sulfate chains may be tightly regulated by the cooperative expression of chondroitin synthase-1 and chondroitin N-acetylgalactosaminyltransferase-1 in peripheral neurons and peripheral neuropathies PMID: 23811343
5. The present study focused on the expression of chondroitin-synthesizing enzymes in colorectal cancer. PMID: 21468578
6. conclude that CHSY1 is a secreted FRINGE enzyme required for adjustment of NOTCH signaling throughout human and fish embryogenesis and particularly during limb patterning PMID: 21129727
7. unrestricted Bmp2b signaling or loss of Dan activity leads to reduced chsy1 expression and, during epithelial morphogenesis, defects similar to those that occur upon Chsy1 inactivation PMID: 21129728
8. chondroitin polymerizing activity requires concomitant expression of a ChPF with ChSy; coexpression of the ChPF and ChSy yielded markedly augmented glycosyltransferase activities, whereas simple mixing of the two separately expressed proteins did not. PMID: 12716890

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HGNC: 17198

OMIM: 605282

KEGG: hsa:22856

STRING: 9606.ENSP00000254190

UniGene: Hs.110488