CLDN17 Antibody

Code CSB-PA004868
Size US$100
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  • Western Blot analysis of Raji BT474 K562 mouse heart mouse skeletal muscle cells using Claudin-17 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
CLDN17
Alternative Names
CLDN17; UNQ758/PRO1489; Claudin-17
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the C-terminal region of Human Claudin-17.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:20000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Channel-forming tight junction protein with selectivity for anions, including chloride and bicarbonate, and for solutes smaller than 9 Angstrom in diameter. In the kidney proximal tubule, may be involved in quantitative reabsorption of filtered anions. Does not affect water permeability.
Gene References into Functions
  1. The structural features of Cldn17 contributing to anion channel formation are presented in this work. PMID: 26194246
  2. Claudin 17 expression was down-regulated in gastric cancer. PMID: 24325792
  3. CLDN17, clustered with CLDN8 at human chromosome 21q22.11, is a four-transmembrane protein with WWCC motif, defined by W-X(17-22)-W-X(2)-C-X(8-10)-C. PMID: 12736707
Subcellular Location
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Protein Families
Claudin family
Tissue Specificity
In the kidney, expressed in the proximal tubule and in the Henle's loop. In the distal convoluted tubule, not expressed in all tubules. Not detected in the collecting duct (at protein level).
Database Links

HGNC: 2038

OMIM: 617005

KEGG: hsa:26285

STRING: 9606.ENSP00000286808

UniGene: Hs.258589

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