CLEC10A Antibody

Code CSB-PA811601LA01HU
Size US$166
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Image
  • IHC image of CSB-PA811601LA01HU diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • Immunofluorescence staining of HepG2 cells with CSB-PA811601LA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CLEC10A Polyclonal antibody
Uniprot No.
Target Names
CLEC10A
Alternative Names
C type (calcium dependent carbohydrate recognition domain) lectin superfamily member 13 (macrophage derived) antibody; C type (calcium dependent carbohydrate recognition domain) lectin superfamily member 14 (macrophage derived) antibody; C type lectin domain family 10; member A antibody; C type lectin superfamily member 14 antibody; C-type lectin domain family 10 member A antibody; C-type lectin superfamily member 14 antibody; CD301 antibody; CD301 antigen antibody; CD301A antibody; CLC10_HUMAN antibody; CLEC10A antibody; CLECSF13 antibody; CLECSF14 antibody; HML antibody; HML2 antibody; Lectin antibody; Macrophage C type lectin antibody; MACROPHAGE GALACTOSE-TYPE C-TYPE antibody; Macrophage lectin 2 (calcium dependent) antibody; Macrophage lectin 2 antibody; MGL antibody; Mgl1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human C-type lectin domain family 10 member A protein (66-316AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The CLEC10A Antibody (Product code: CSB-PA811601LA01HU) is Non-conjugated. For CLEC10A Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA811601LB01HU CLEC10A Antibody, HRP conjugated ELISA
FITC CSB-PA811601LC01HU CLEC10A Antibody, FITC conjugated
Biotin CSB-PA811601LD01HU CLEC10A Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells.
Gene References into Functions
  1. this paper shows that key gene of intermediate proinflammatory monocytes, such as CLEC10A, is expressed three- to fourfold more in juvenile idiopathic arthritis-enthesitis-related arthritis PMID: 27706807
  2. BRAF(V600E) mutation induces MGL ligand expression, thereby providing a direct link between oncogenic transformation and aberrant expression of immunosuppressive glycans in colorectal neoplasms. PMID: 26172302
  3. These results indicate a role of MGL as an immunomodulator within the tumour microenvironment interfering with Treg functions, suggesting its possible use in the design of anticancer vaccines. PMID: 26147970
  4. expression of GalNAc moieties mirrors the T cell activation status, and thus only highly stimulated T cells are prone to the suppressive action of MGL. PMID: 23918927
  5. MGL triggering synergized with TLR2-induced pathways, leading to elevated IL-10 mRNA levels & enhanced TNF-alpha mRNA stability. It promoted phosphorylation of the ERK & CREB, fine-tuning the DC maturation phenotype. PMID: 23744646
  6. Described is the use of recombinant CLEC10A (CD301), a human glycoreceptor of the C-type lectin family, for the detection of ligands in sections from formalin-fixed, paraffin-embedded normal and cancerous mammary tissues. PMID: 23275449
  7. MGL engagement improved DC performance as antigen-presenting cells, promoting the upregulation of maturation markers, a decrease in phagocytosis, an enhancement of motility, and most importantly an increase in antigen-specific CD8(+) T-cell activation. PMID: 22531918

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Subcellular Location
Membrane; Single-pass type II membrane protein.
Database Links

HGNC: 16916

OMIM: 605999

KEGG: hsa:10462

STRING: 9606.ENSP00000254868

UniGene: Hs.54403

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