CLPS Antibody

Code CSB-PA005578LA01HU
Size US$166
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Image
  • IHC image of CSB-PA005578LA01HU diluted at 1:400 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CLPS Polyclonal antibody
Uniprot No.
Target Names
CLPS
Alternative Names
clpS antibody; COL_HUMAN antibody; Colipase antibody; Colipase pancreatic antibody; Pancreatic colipase preproprotein antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Colipase protein (23-112AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The CLPS Antibody (Product code: CSB-PA005578LA01HU) is Non-conjugated. For CLPS Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA005578LB01HU CLPS Antibody, HRP conjugated ELISA
FITC CSB-PA005578LC01HU CLPS Antibody, FITC conjugated
Biotin CSB-PA005578LD01HU CLPS Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:200-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.; Enterostatin has a biological activity as a satiety signal.
Gene References into Functions
  1. Low CLPS expression is associated with pancreatic cancer. PMID: 23918603
  2. humans with the Arg92Cys substitution will secrete less functional colipase PMID: 23204298
  3. found no evidence for an association of pancreatic colipase(CLPS) single nucleotide polymorphisms rs2766597, rs41270082, rs3748050, and rs3748051 with obesity or percentage of dietary fat intake PMID: 20054203
  4. evidence in two German Caucasian study populations that the variant of the rare colipase Arg109Cys polymorphism might contribute to increased susceptibility of type 2 diabetes PMID: 16189801
  5. Our findings demonstrate that the Arg92Cys polymorphism decreases the function of Cys92 colipase. This change may contribute to the development of type 2 diabetes. PMID: 17715423
  6. CLPS genetic variability associates with insulin secretory function in non-diabetic humans and may represent a novel candidate gene for development of type 2 diabetes PMID: 18726866

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Subcellular Location
Secreted.
Protein Families
Colipase family
Tissue Specificity
Expressed by the pancreas.
Database Links

HGNC: 2085

OMIM: 120105

KEGG: hsa:1208

STRING: 9606.ENSP00000259938

UniGene: Hs.1340

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