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CLSTN3 Antibody, HRP conjugated

Datasheet
Code CSB-PA871555LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CLSTN3 Polyclonal antibody
Uniprot No.
Q9BQT9
Target Names
CLSTN3
Alternative Names
CLSTN3 antibody; CS3 antibody; KIAA0726Calsyntenin-3 antibody; Alcadein-beta antibody; Alc-beta antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Calsyntenin-3 protein (197-408AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation.
Gene References into Functions
  1. ApoE expression attenuated intracellular trafficking of APP and Alcbeta PMID: 26213366
  2. structure of Calsyntenin 3 and its interaction with neurexin 1alpha PMID: 25352602
  3. The C-terminal fragment but not full-length Cst-3 accumulated in dystrophic neurites surrounding amyloidbeta plaques in Tg2576 mouse and Alzheimer disease brains. PMID: 23499467
  4. Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation [alcalpha1, alcbeta, alcgamma] PMID: 15037614
Subcellular Location
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane. Golgi apparatus membrane. Cell junction, synapse, postsynapse. Cell projection, dendrite.
Tissue Specificity
According to PubMed:12498782, expressed predominantly in the brain and in kidney. Low levels in heart, skeletal muscle, liver, placenta, pancreas and lung. According to PubMed:12972431, predominant expression in brain, and only marginal in kidney. In brai
Database Links

HGNC: 18371

OMIM: 611324

KEGG: hsa:9746

UniGene: Hs.535378

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