CLYBL Antibody

Code CSB-PA005598GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
CLYBL
Alternative Names
CLYBL antibody; CLB antibody; Citramalyl-CoA lyase antibody; mitochondrial antibody; EC 4.1.3.25; antibody; 3S)-malyl-CoA thioesterase antibody; EC 3.1.2.30 antibody; Beta-methylmalate synthase antibody; EC 2.3.3.- antibody; Citrate lyase subunit beta-like protein antibody; Citrate lyase beta-like antibody; Malate synthase antibody; EC 2.3.3.9 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human CLYBL
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism. Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway. The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite. Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate. Also displays malyl-CoA thioesterase activity. Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate. Also has very weak citramalate synthase activity in vitro.
Gene References into Functions
  1. Study reports that CLYBL loss leads to a cell-autonomous defect in the mitochondrial B12 metabolism and that itaconyl-CoA is a cofactor-inactivating, substrate-analog inhibitor of the mitochondrial B12-dependent methylmalonyl-CoA mutase PMID: 29056341
Subcellular Location
Mitochondrion.
Protein Families
HpcH/HpaI aldolase family, Citrate lyase beta subunit-like subfamily
Database Links

HGNC: 18355

OMIM: 609686

KEGG: hsa:171425

STRING: 9606.ENSP00000342991

UniGene: Hs.655642

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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