CMTR2 Antibody

Datasheet

Code	CSB-PA812902LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA812902LA01HU at dilution of 1:100 Immunofluorescent analysis of MCF-7 cells using CSB-PA812902LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CMTR2 Polyclonal antibody

Uniprot No.

Q8IYT2

Target Names

CMTR2

Alternative Names

CMTR2; AFT; FTSJD1; Cap-specific mRNA; nucleoside-2'-O--methyltransferase 2; Cap methyltransferase 2; Cap2 2'O-ribose methyltransferase 2; HMTr2; MTr2; FtsJ methyltransferase domain-containing protein 1; Protein adrift homolog

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Cap-specific mRNA (nucleoside-2\'-O-)-methyltransferase 2 protein (301-600AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CMTR2 Antibody (Product code: CSB-PA812902LA01HU) is Non-conjugated. For CMTR2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA812902LB01HU	CMTR2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA812902LC01HU	CMTR2 Antibody, FITC conjugated
Biotin	CSB-PA812902LD01HU	CMTR2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the second nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) (cap0) to produce m(7)GpppRmpNm (cap2). Recognizes a guanosine cap on RNA independently of its N(7) methylation status. Display cap2 methylation on both cap0 and cap1. Displays a preference for cap1 RNAs.

Gene References into Functions

Crystal structures of the active CMTr2 catalytic domain in complex with a methyl group donor and a capped oligoribonucleotide are examined, thereby revealing the mechanism of specific recognition of capped RNA. PMID: 24402442
A report on the validation of a human enzyme that methylates the ribose of the second transcribed nucleotide encoded by FTSJD1. PMID: 21310715

Subcellular Location

Nucleus. Cytoplasm.

Database Links

HGNC: 25635

OMIM: 616190

KEGG: hsa:55783

STRING: 9606.ENSP00000337512

UniGene: Hs.72782

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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