COL25A1 Antibody

Code CSB-PA005735GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
COL25A1
Alternative Names
COL25A1Collagen alpha-1(XXV) chain antibody; Alzheimer disease amyloid-associated protein antibody; AMY antibody; CLAC-P) [Cleaved into: Collagen-like Alzheimer amyloid plaque component antibody; CLAC)] antibody
Species Reactivity
Human,Mouse,Rat
Immunogen
Human COL25A1
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin.
Gene References into Functions
  1. We highlight phenotypes of the 4 affected children from the 2 reported families: isolated congenital ptosis (one unilateral, one bilateral) and Duane syndrome (one unilateral, one bilateral) with synergistic divergence. PMID: 26486031
  2. We identified COL25A1 mutations as a cause of autosomal-recessive congenital cranial dysinnervation disorder. PMID: 25500261
  3. COL25A1 methylation correlates with severity of cervical intraepithelial neoplasia PMID: 23018867
  4. The COL25A1 single nucleotide polymorphism rs13134663 was significantly associated with antisocial personality disorder, especially in subjects with comorbid substance dependence. PMID: 22297151
  5. The next best locus for gene x gender interactions for age at onset was in COL25A1 gene at 4q25 PMID: 21688384
  6. provides genetic evidence of association between COL25A1 and risk for Alzheimer's disease PMID: 18501477
  7. COL25A1 leads to Alzheimer's disease-like pathology in vivo PMID: 19548013
  8. CLAC displays features characteristic of a collagen protein, ie. it forms a partly protease-resistant triple-helical structure, exhibits an intermediate affinity for heparin, and is glycosylated; binding domain between CLAC and amyloid beta-peptide PMID: 15522881
  9. CLACbinds to amyloid beta peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils PMID: 15615705
  10. Results show that collagenous Alzheimer amyloid plaque component (CLAC) assembles amyloid-beta fibrils into fibril bundles that have an increased resistance to proteases. PMID: 15853808
  11. suggest that CLAC becomes involved at an intermediate stage in the pathogenesis of Alzheimer's disease by binding to Abeta fibrils, including fibrils formed from peptides with truncated N- or C-termini, and thereby slows their growth PMID: 16300410

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Involvement in disease
Fibrosis of extraocular muscles, congenital, 5 (CFEOM5)
Subcellular Location
Membrane; Single-pass type II membrane protein. Note=After proteolytic cleavage, CLAC is secreted.
Tissue Specificity
Expressed predominantly in brain. Deposited preferentially in primitive or neuritic amyloid plaques which are typical of Alzheimer disease.
Database Links

HGNC: 18603

OMIM: 610004

KEGG: hsa:84570

STRING: 9606.ENSP00000382083

UniGene: Hs.658842

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