COL25A1 Antibody

Code CSB-PA070029
Size US$167
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Product Details

Uniprot No. Q9BXS0
Target Names COL25A1
Alternative Names COL25A1Collagen alpha-1(XXV) chain antibody; Alzheimer disease amyloid-associated protein antibody; AMY antibody; CLAC-P) [Cleaved into: Collagen-like Alzheimer amyloid plaque component antibody; CLAC)] antibody
Raised in Rabbit
Species Reactivity Human,Mouse
Immunogen Synthesized peptide derived from the Internal region of Human COL25A1.
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Tested Applications WB, IHC, IF, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:20000
Protocols Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin.
Gene References into Functions
  1. We highlight phenotypes of the 4 affected children from the 2 reported families: isolated congenital ptosis (one unilateral, one bilateral) and Duane syndrome (one unilateral, one bilateral) with synergistic divergence. PMID: 26486031
  2. We identified COL25A1 mutations as a cause of autosomal-recessive congenital cranial dysinnervation disorder. PMID: 25500261
  3. COL25A1 methylation correlates with severity of cervical intraepithelial neoplasia PMID: 23018867
  4. The COL25A1 single nucleotide polymorphism rs13134663 was significantly associated with antisocial personality disorder, especially in subjects with comorbid substance dependence. PMID: 22297151
  5. The next best locus for gene x gender interactions for age at onset was in COL25A1 gene at 4q25 PMID: 21688384
  6. provides genetic evidence of association between COL25A1 and risk for Alzheimer's disease PMID: 18501477
  7. COL25A1 leads to Alzheimer's disease-like pathology in vivo PMID: 19548013
  8. CLAC displays features characteristic of a collagen protein, ie. it forms a partly protease-resistant triple-helical structure, exhibits an intermediate affinity for heparin, and is glycosylated; binding domain between CLAC and amyloid beta-peptide PMID: 15522881
  9. CLACbinds to amyloid beta peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils PMID: 15615705
  10. Results show that collagenous Alzheimer amyloid plaque component (CLAC) assembles amyloid-beta fibrils into fibril bundles that have an increased resistance to proteases. PMID: 15853808
  11. suggest that CLAC becomes involved at an intermediate stage in the pathogenesis of Alzheimer's disease by binding to Abeta fibrils, including fibrils formed from peptides with truncated N- or C-termini, and thereby slows their growth PMID: 16300410

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Involvement in disease Fibrosis of extraocular muscles, congenital, 5 (CFEOM5)
Subcellular Location Membrane, Single-pass type II membrane protein
Tissue Specificity Expressed predominantly in brain. Deposited preferentially in primitive or neuritic amyloid plaques which are typical of Alzheimer disease.
Database Links

HGNC: 18603

OMIM: 610004

KEGG: hsa:84570

STRING: 9606.ENSP00000382083

UniGene: Hs.658842

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