CORO7 Antibody

Datasheet

Code	CSB-PA005819LA01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CORO7 Polyclonal antibody

Uniprot No.

P57737

Target Names

CORO7

Alternative Names

0610011B16Rik antibody; 70 kDa WD repeat tumor rejection antigen homolog antibody; CORO 7 antibody; Coro7 antibody; CORO7_HUMAN antibody; Coronin-7 antibody; Coronin7 antibody; Crn7 antibody; FLJ22021 antibody; FLJ44188 antibody; POD1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Coronin-7 protein (630-900AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CORO7 Antibody (Product code: CSB-PA005819LA01HU) is Non-conjugated. For CORO7 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA005819LB01HU	CORO7 Antibody, HRP conjugated	ELISA
FITC	CSB-PA005819LC01HU	CORO7 Antibody, FITC conjugated
Biotin	CSB-PA005819LD01HU	CORO7 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.

Gene References into Functions

Obese children had significantly lower methylation levels at a CpG site located near coronin 7 (CORO7), which encodes a tryptophan-aspartic acid dipeptide (WD)-repeat containing protein most likely involved in Golgi complex morphology and function PMID: 25887538
Results show that enforced targeting of Crn7 to TGN 9trans-Golgi network) bypasses the requirement of K33-ubiquitination for TGN-pool F-actin assembly and post-Golgi trafficking. PMID: 24768539
Data show that CRN7 interacted with Cullin1 and Roc1 to form a novel SCF-like E3 complex. PMID: 21130766
role in the organization of intracellular membrane compartments and vesicular trafficking rather than in remodeling the cytoskeleton PMID: 15327992
Crn7 interacts with AP-1 and is required for the maintenance of Golgi morphology and protein export from the Golgi PMID: 16905771
Sequential events of protein interaction and posttranslational modification result in the membrane targeting of Crn7. PMID: 18581049

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Subcellular Location

Golgi apparatus membrane. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle. Cytoplasm, cytosol. Note=Predominantly cytosolic. Detected on vesicle-like cytoplasmic structures and on the cis-Golgi. Not associated with actin filaments.

Protein Families

WD repeat coronin family

Tissue Specificity

Widely expressed. Expressed in the spleen, peripheral leukocytes, testes, brain, thymus and small intestine.

Database Links

HGNC: 26161

OMIM: 611668

KEGG: hsa:79585

STRING: 9606.ENSP00000460885

UniGene: Hs.437957

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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