COX15 Antibody

Code CSB-PA005827GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
COX15
Alternative Names
CEMCOX2 antibody; COX15 antibody; COX15 homolog; cytochrome c oxidase assembly protein antibody; COX15; S. cerevisiae; homolog of antibody; COX15_HUMAN antibody; cytochrome c oxidase assembly homolog 15 (yeast) antibody; Cytochrome c oxidase assembly protein COX15 homolog antibody; cytochrome c oxidase subunit 15 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human COX15
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May be involved in the biosynthesis of heme A.
Gene References into Functions
  1. Mutations of COX15 causing single amino acid conversions are associated with fatal infantile hypertrophic cardiomyopathy and the neurological disorder Leigh syndrome. PMID: 26940873
  2. Mutations in COX15 produce a defect in the mitochondrial heme biosynthetic pathway, causing early-onset fatal hypertrophic cardiomyopathy PMID: 12474143
  3. A patient with typical clinical and neuroradiological features of Leigh syndrome and cytochrome oxidase deficiency was found to have a mutation in the COX15 gene. PMID: 15235026
  4. cdkl3 transfected in anchorage-independent (suspension) HeLa cells overexpressed relative to attached cells and lead to elevated proliferation and viability relative to untransfected. Same in two HEK-293 and a CHO cell lines. PMID: 17945021
Involvement in disease
Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 2 (CEMCOX2); Leigh syndrome (LS)
Subcellular Location
Mitochondrion membrane; Multi-pass membrane protein.
Protein Families
COX15/CtaA family
Tissue Specificity
Predominantly found in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle, heart, and brain.
Database Links

HGNC: 2263

OMIM: 256000

KEGG: hsa:1355

STRING: 9606.ENSP00000016171

UniGene: Hs.28326

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