COX15 Antibody

Datasheet

Code	CSB-PA759167LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Rat kidney tissue All lanes: COX15 antibody at 3.4μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 47, 44 kDa Observed band size: 47 kDa IHC image of CSB-PA759167LA01HU diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) COX15 Polyclonal antibody

Uniprot No.

Q7KZN9

Target Names

COX15

Alternative Names

CEMCOX2 antibody; COX15 antibody; COX15 homolog; cytochrome c oxidase assembly protein antibody; COX15; S. cerevisiae; homolog of antibody; COX15_HUMAN antibody; cytochrome c oxidase assembly homolog 15 (yeast) antibody; Cytochrome c oxidase assembly protein COX15 homolog antibody; cytochrome c oxidase subunit 15 antibody

Raised in

Rabbit

Species Reactivity

Human, Rat

Immunogen

Recombinant Human Cytochrome c oxidase assembly protein COX15 homolog protein (1-67AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The COX15 Antibody (Product code: CSB-PA759167LA01HU) is Non-conjugated. For COX15 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA759167LB01HU	COX15 Antibody, HRP conjugated	ELISA
FITC	CSB-PA759167LC01HU	COX15 Antibody, FITC conjugated
Biotin	CSB-PA759167LD01HU	COX15 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

May be involved in the biosynthesis of heme A.

Gene References into Functions

Mutations of COX15 causing single amino acid conversions are associated with fatal infantile hypertrophic cardiomyopathy and the neurological disorder Leigh syndrome. PMID: 26940873
Mutations in COX15 produce a defect in the mitochondrial heme biosynthetic pathway, causing early-onset fatal hypertrophic cardiomyopathy PMID: 12474143
A patient with typical clinical and neuroradiological features of Leigh syndrome and cytochrome oxidase deficiency was found to have a mutation in the COX15 gene. PMID: 15235026
cdkl3 transfected in anchorage-independent (suspension) HeLa cells overexpressed relative to attached cells and lead to elevated proliferation and viability relative to untransfected. Same in two HEK-293 and a CHO cell lines. PMID: 17945021

Involvement in disease

Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 2 (CEMCOX2); Leigh syndrome (LS)

Subcellular Location

Mitochondrion membrane; Multi-pass membrane protein.

Protein Families

COX15/CtaA family

Tissue Specificity

Predominantly found in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle, heart, and brain.

Database Links

HGNC: 2263

OMIM: 256000

KEGG: hsa:1355

STRING: 9606.ENSP00000016171

UniGene: Hs.28326

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Service

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Antibody Service

Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Oxidative Phosphorylation

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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