COX7B Antibody

Code CSB-PA017662
Size US$299 How to order?
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA017662(COX7B Antibody) at dilution 1/70, on the right is treated with fusion protein. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA017662(COX7B Antibody) at dilution 1/70, on the right is treated with fusion protein. (Original magnification: ×200)
  • Gel: 10+15%SDS-PAGE, Lysate: 50 μg, Lane: 293T cells, Primary antibody: CSB-PA017662(COX7B Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
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Product Details

Uniprot No. P24311
Target Names COX7B
Alternative Names COX7B antibody; COX7B_HUMAN antibody; Cytochrome c oxidase chain VIIb antibody; Cytochrome c oxidase polypeptide VIIb antibody; Cytochrome c oxidase subunit 7B antibody; Cytochrome c oxidase subunit 7B mitochondrial antibody; Cytochrome c oxidase subunit VIIb antibody; mitochondrial antibody
Raised in Rabbit
Species Reactivity Human,Rat
Immunogen Fusion protein of Human COX7B
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method Antigen affinity purification
Concentration It differs from different batches. Please contact us to confirm it.
Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form Liquid
Tested Applications ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:5000
WB 1:500-1:2000
IHC 1:100-1:300
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Plays a role in proper central nervous system (CNS) development in vertebrates.
Gene References into Functions
  1. study analyzed the X-linked COX7B and found deleterious de novo mutations in two simplex cases of microphthalmia with linear skin lesions and a nonsense mutation, which segregates with the disease, in a familial case PMID: 23122588
  2. Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 7b PMID: 20307258
Involvement in disease Linear skin defects with multiple congenital anomalies 2 (LSDMCA2)
Subcellular Location Mitochondrion inner membrane; Single-pass membrane protein.
Protein Families Cytochrome c oxidase VIIb family
Database Links

HGNC: 2291

OMIM: 300885

KEGG: hsa:1349

STRING: 9606.ENSP00000417656

UniGene: Hs.522699

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