CPLX2 Antibody

1. This study demonstrated that complexin-II differentially influence cognitive function in early and late stages of Alzheimer's disease. PMID: 27866231
2. Then results indicated that CPLX2 may be involved in the etiology of schizophrenia and one of its potential biological mechanisms by studying the effects of CPLX2 risk variants on working memory load-dependent neural activity in a frontoparietal network. PMID: 25297695
3. These results suggested that CPLX2 participated in synaptic taste transduction. PMID: 25692331
4. CPLX2 rs1366116*T variant represents a risk factor of schizophrenia, and , at the same time, CPLX2 rs3892909*T variant is protective against schizophrenia (study performed in Armenians). PMID: 25564026
5. role in synaptic vesicle exocytosis PMID: 12058476
6. altered immunoreactivity of this protein in prefrontal cortex in severe mental illness PMID: 12082566
7. in huntingtin mutation, the decline in neurotransmitter release is a direct consequence of complexin II depletion PMID: 12807877
8. In schizophrenia, complexin II was reduced in dorsolateral prefrontal cortex and superior temporal cortex. The impairment of synaptic transmission may contribute to the dysfunction of cortical neural circuits that characterises the disorder. PMID: 15653259
9. CX2 level increased between the fetal and the 6-10 years groups and then plateaued PMID: 18240322

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HGNC: 2310

OMIM: 605033

KEGG: hsa:10814

STRING: 9606.ENSP00000352544

UniGene: Hs.193235