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CPLX2 Antibody

Datasheet
Code CSB-PA761369ESR2HU
Size US$166
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  • Western Blotting(WB) - CPLX2 Antibody

    Western blot
    All lanes: Complexin-2 antibody at 6μg/ml
    Lane 1: Rat brain tissue
    Lane 2: A549 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 15 kDa
    Observed band size: 15 kDa
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CPLX2 Polyclonal antibody
Uniprot No.
Q6PUV4
Target Names
CPLX2
Alternative Names
921 L antibody; Complexin 2 antibody; Complexin II antibody; Complexin-2 antibody; Complexin2 antibody; ComplexinII antibody; CPLX 2 antibody; Cplx2 antibody; CPLX2_HUMAN antibody; CPX 2 antibody; CPX II antibody; CPXII antibody; Hfb1 antibody; Synaphin 1 antibody; Synaphin-1 antibody; Synaphin1 antibody
Raised in
Rabbit
Species Reactivity
Human, Rat
Immunogen
Recombinant Human Complexin-2 protein (1-134AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
Protocols
ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis.
Gene References into Functions
  1. This study demonstrated that complexin-II differentially influence cognitive function in early and late stages of Alzheimer's disease. PMID: 27866231
  2. Then results indicated that CPLX2 may be involved in the etiology of schizophrenia and one of its potential biological mechanisms by studying the effects of CPLX2 risk variants on working memory load-dependent neural activity in a frontoparietal network. PMID: 25297695
  3. These results suggested that CPLX2 participated in synaptic taste transduction. PMID: 25692331
  4. CPLX2 rs1366116*T variant represents a risk factor of schizophrenia, and , at the same time, CPLX2 rs3892909*T variant is protective against schizophrenia (study performed in Armenians). PMID: 25564026
  5. role in synaptic vesicle exocytosis PMID: 12058476
  6. altered immunoreactivity of this protein in prefrontal cortex in severe mental illness PMID: 12082566
  7. in huntingtin mutation, the decline in neurotransmitter release is a direct consequence of complexin II depletion PMID: 12807877
  8. In schizophrenia, complexin II was reduced in dorsolateral prefrontal cortex and superior temporal cortex. The impairment of synaptic transmission may contribute to the dysfunction of cortical neural circuits that characterises the disorder. PMID: 15653259
  9. CX2 level increased between the fetal and the 6-10 years groups and then plateaued PMID: 18240322

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Subcellular Location
Cytoplasm, cytosol. Cell junction, synapse, presynapse. Nucleus. Perikaryon.
Protein Families
Complexin/synaphin family
Tissue Specificity
Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with sc
Database Links

HGNC: 2310

OMIM: 605033

KEGG: hsa:10814

STRING: 9606.ENSP00000352544

UniGene: Hs.193235

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Related pathways
Synaptic vesicle cycle
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