CPSF4 Antibody

1. The authors define the molecular architecture of the core human CPSF complex comprising CPSF160, WDR33, CPSF30 and Fip1 and identify specific domains involved in inter-subunit interactions. Together, these results shed light on the function of CPSF in mediating polyA signal-dependent RNA cleavage and polyadenylation. PMID: 29274231
2. Residues F103 and M106 within the NS1-CPSF4 binding region are important for viral replication. PMID: 28554059
3. Cleavage and polyadenylation specific factor 4 targets NF-kappaB/cyclooxygenase-2 signaling to promote the growth and survival of non-small cell lung carcinoma cells. PMID: 27450326
4. These findings support a role for iron in some zinc-finger proteins. Using electrophoretic mobility shift assays and fluorescence anisotropy, we report that CPSF30 selectively recognizes the AU-rich hexamer (AAUAAA) sequence present in pre-mRNA, providing the first molecular-based evidence to our knowledge for CPSF30/RNA binding. PMID: 27071088
5. unexpectedly found that CPSF subunits CPSF30 and Wdr33 directly contact AAUAAA PMID: 25301780
6. CPSF4 upregulates human TERT promoter activity, human TERT expression and telomerase activity. PMID: 24618080
7. Data show that 4 drug-like compounds from traditional Chinese Medicine (TCM) database were selected as potential inhibitors for the cleavage and polyadenylation specific factor CPSF30-binding site of influenza A virus of non-structural protein 1 (NS1A). PMID: 24562912
8. CPSF4 plays a critical role in regulating lung cancer cell proliferation and survival and may be a potential prognostic biomarker and therapeutic target for lung adenocarcinoma. PMID: 24358221
9. Data show that the NS1A protein of the pathogenic H5N1 influenza A/Hong Kong/483/97 (HK97) virus isolated from humans has an intrinsic defect in CPSF30 binding. PMID: 17522219

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HGNC: 2327

OMIM: 603052

KEGG: hsa:10898

STRING: 9606.ENSP00000292476

UniGene: Hs.489287