CREBZF Antibody

1. Zhangfei/CREBZF stabilizes p53 and co-localizes with it in cellular nuclei; the bLZip domain of Zhangfei is required for its profound effects on cell growth and interaction with p53. PMID: 24200963
2. Zhangfei had a suppressive effect on most unfolded protein response genes. PMID: 24155933
3. Results indicate that Ursodeoxycholic acid (UDCA) activates SMILE gene expression, which leads to repression of liver X receptor alpha (LXRalpha)-mediated hepatic lipogenic enzyme gene expression. PMID: 24265317
4. Our objective was to determine the molecular mechanisms by which Zhangfei influences medulloblastoma cell lines PMID: 22798206
5. The transcription factor CREBZF is a novel positive regulator of p53. PMID: 22983008
6. CREBZF, a novel Smad8-binding protein. PMID: 22707059
7. a microarray study of SMILE knock-down and PMA activation in HeLa cells was compared to earlier analysis based on microarray data of kidney allograft tolerance and rejection to determine possible new genes and gene networks involved in kidney transplantation PMID: 22134986
8. the curcumin/LKB1/AMPK/SMILE/PGC1alpha pathway differentially regulates ER stress-mediated gene transcription PMID: 21994947
9. SMILE is involved in the endoplasmic reticulum stress response, by modulating proteasome activity and XBP-1 transcript expression. This function of SMILE may influence immune cell behavior in the context of transplantation. PMID: 21603654
10. These results indicate that SMILE isoforms regulate the inhibition of estrogen receptor transactivation by SHP in a cell-type-specific manner and act as a novel transcriptional co-regulator in ER signalling. PMID: 18657049
11. findings showed Zhangfei activated the expression of trkA and Egr1 in medulloblastoma cells and caused these cells to display markers of apoptosis PMID: 18719857
12. SMILE is a novel corepressor of ERRgamma, and SIRT1 has a role as a novel repressive mechanism for SMILE and ERRgamma inverse agonist PMID: 19690166
13. ZF suppresses the ability of Luman/CREB3 to activate gene expression PMID: 15705566
14. ZF suppresses the ability of VP16 to activate herpes simplex virus IE gene expression PMID: 16282471
15. ZF binds ATF4/CREB2 and enhances its response to MEK1 activation. PMID: 16343488
16. Zhangfei causes medulloblastoma cells to undergo apoptosis PMID: 18719857
17. In differentiated PC12 cells, Zhangfei activated the trkA promoter and induced the expression of endogenous trkA. PMID: 19016376

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HGNC: 24905

OMIM: 606444

KEGG: hsa:58487

STRING: 9606.ENSP00000433459

UniGene: Hs.535319