CRISPLD2 Antibody

1. Our results suggest that CRISPLD2 rs4783099 may represent a risk factor for NSCPO (non-syndromic oral clefts). PMID: 27328068
2. Data suggest that suppression of CRISPLD2 increases the risk of lung inflammation in early life and adulthood. PMID: 27597766
3. Our data suggest that CRISPLD2 may have a unique anti-HMGB1 effect via miRNA155 and play an important role in immune balance. PMID: 26624800
4. CRISPLD2 is a target of progesterone receptor and its expression is decreased in women with endometriosis. PMID: 24955763
5. Results demonstrate genetic polymorphism of CRISPLD2 gene is associated with an increased risk of non-syndromic cleft lip with or without cleft palate. PMID: 25496823
6. findings define a role for LGL1 in fibroblast expansion and migration, epithelial cell migration, and mesenchymal-epithelial signaling, key processes in fetal lung development. PMID: 25480331
7. results support the hypothesis that variants in the CRISPLD2 gene may be involved in the etiology of NS CL(P). PMID: 20815724
8. Both LCCL-domains of human CRISPLD2 have high affinity for lipid A. PMID: 24090571
9. There is a decreased expression of CRISPLD2 in septic shock and it is association with procalcitonin in sepsis. PMID: 23799041
10. CRISPLD2 gene contributes to the etiology of NSCLP in the Northwestern Chinese population. SNP rs1546124 is significantly related to NSCLP, associated with both CL/P and CPO groups, and SNP rs4783099 is significantly associated with CPO. PMID: 21800413
11. the present investigation did not support the hypothesis of the involvement of CRISPLD2 in nonsyndromic cleft lip and palate PMID: 21244519
12. three SNPs in northern Chinese population found an association between these polymorphisms and NSCLP in both single-marker and haplotype analyses. data further strengthen the conclusion that altered CRISPLD2 is associated with NSCLP susceptibility. PMID: 20662919
13. CRISPLD2 is expressed in the mandible, palate and nasopharynx regions during craniofacial development at E13.5-E17.5, respectively. Altogether, these data suggest that genetic variation in CRISPLD2 has a role in the etiology of NSCLP. PMID: 17616516
14. present work introduces mammal CRISPLD2 as a major serum protein that acts as a natural LPS antagonist and promises to be of considerable preventative value against endotoxic shock. PMID: 19864597

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HGNC: 25248

OMIM: 612434

KEGG: hsa:83716

STRING: 9606.ENSP00000262424

UniGene: Hs.513779