Product Details

Purity

Greater than 85% as determined by SDS-PAGE.

Target Names

CRISPLD2

Uniprot No.

Q9H0B8

Research Area

Signal Transduction

Alternative Names

CRISP-11; CRISP11; Crispld2; CRLD2_HUMAN; Cysteine-rich secretory protein 11; Cysteine-rich secretory protein LCCL domain-containing 2; DKFZP434B044; LCCL domain-containing cysteine-rich secretory protein 2; LCRISP2; MGC74865

Species

Homo sapiens (Human)

Source

Mammalian cell

Expression Region

23-497a

Target Protein Sequence

YLLPNVTLLEELLSKYQHNESHSRVRRAIPREDKEEILMLHNKLRGQVQPQASNMEYMTWDDELEKSAAAWASQCIWEHGPTSLLVSIGQNLGAHWGRYRSPGFHVQSWYDEVKDYTYPYPSECNPWCPERCSGPMCTHYTQIVWATTNKIGCAVNTCRKMTVWGEVWENAVYFVCNYSPKGNWIGEAPYKNGRPCSECPPSYGGSCRNNLCYREETYTPKPETDEMNEVETAPIPEENHVWLQPRVMRPTKPKKTSAVNYMTQVVRCDTKMKDRCKGSTCNRYQCPAGCLNHKAKIFGTLFYESSSSICRAAIHYGILDDKGGLVDITRNGKVPFFVKSERHGVQSLSKYKPSSSFMVSKVKVQDLDCYTTVAQLCPFEKPATHCPRIHCPAHCKDEPSYWAPVFGTNIYADTSSICKTAVHAGVISNESGGDVDVMPVDKKKTYVGSLRNGVQSESLGTPRDGKAFRIFAVRQ
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.

Mol. Weight

58.8

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal 10xHis-tagged and C-terminal Myc-tagged

Form

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer

Tris-based buffer，50% glycerol

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

3-7 business days

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet & COA

Please contact us to get it.

Target Background

Function

Promotes matrix assembly.

Gene References into Functions

Our results suggest that CRISPLD2 rs4783099 may represent a risk factor for NSCPO (non-syndromic oral clefts). PMID: 27328068
Data suggest that suppression of CRISPLD2 increases the risk of lung inflammation in early life and adulthood. PMID: 27597766
Our data suggest that CRISPLD2 may have a unique anti-HMGB1 effect via miRNA155 and play an important role in immune balance. PMID: 26624800
CRISPLD2 is a target of progesterone receptor and its expression is decreased in women with endometriosis. PMID: 24955763
Results demonstrate genetic polymorphism of CRISPLD2 gene is associated with an increased risk of non-syndromic cleft lip with or without cleft palate. PMID: 25496823
findings define a role for LGL1 in fibroblast expansion and migration, epithelial cell migration, and mesenchymal-epithelial signaling, key processes in fetal lung development. PMID: 25480331
results support the hypothesis that variants in the CRISPLD2 gene may be involved in the etiology of NS CL(P). PMID: 20815724
Both LCCL-domains of human CRISPLD2 have high affinity for lipid A. PMID: 24090571
There is a decreased expression of CRISPLD2 in septic shock and it is association with procalcitonin in sepsis. PMID: 23799041
CRISPLD2 gene contributes to the etiology of NSCLP in the Northwestern Chinese population. SNP rs1546124 is significantly related to NSCLP, associated with both CL/P and CPO groups, and SNP rs4783099 is significantly associated with CPO. PMID: 21800413
the present investigation did not support the hypothesis of the involvement of CRISPLD2 in nonsyndromic cleft lip and palate PMID: 21244519
three SNPs in northern Chinese population found an association between these polymorphisms and NSCLP in both single-marker and haplotype analyses. data further strengthen the conclusion that altered CRISPLD2 is associated with NSCLP susceptibility. PMID: 20662919
CRISPLD2 is expressed in the mandible, palate and nasopharynx regions during craniofacial development at E13.5-E17.5, respectively. Altogether, these data suggest that genetic variation in CRISPLD2 has a role in the etiology of NSCLP. PMID: 17616516
present work introduces mammal CRISPLD2 as a major serum protein that acts as a natural LPS antagonist and promises to be of considerable preventative value against endotoxic shock. PMID: 19864597

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Subcellular Location

Secreted.

Protein Families

CRISP family

Database Links

HGNC: 25248

OMIM: 612434

KEGG: hsa:83716

STRING: 9606.ENSP00000262424

UniGene: Hs.513779

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Code	CSB-MP884430HU
MSDS	MSDS
Size	$660
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Image	(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Recombinant Human Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2)

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